Driver with mild cognitive impairment and visual function

• Project/Area Number: 15K12593
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: TSUTSUMIMOTO Kota 国立研究開発法人国立長寿医療研究センター, 予防老年学研究部, 研究員 (70633189)
• Research Collaborator: SHIMADA Hiroyuki ; SUZUKI Takao ; MAKIZAKO Hyuma ; DOI Takehiko ; HOTTA Ryo ; NAKAKUBO Sho ; MAKINO Keitaro ; YAMADA Minoru ; ONO Rei
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 運転 / 軽度認知障害 / 高齢者

Outline of Final Research Achievements

The value of visual function of our subjects were following, visual depth; 3.29±3.62, kinetic vision; 0.21±0.14, dynamic field of view; 12465.3±2179.3. Only dynamic field of view was associated with brain structure (p = 0.022).This region of brain structure was anterior insula. The previous report suggested that insula had a strong relationship with emotion. The negative emotion led to brain activity of insula.

Research Products

• [Journal Article] Subjective Memory Complaints are Associated with Incident Dementia in Cognitively Intact Older People, but Not in Those with Cognitive Impairment: A 24-Month Prospective Cohort Study. (2017)
  • Author(s): Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H.
  • Journal Title: Am J Geriatr Psychiatry Volume: 25(6) Pages: 607-616
  • Peer Reviewed
• [Journal Article] The association between anorexia of aging and physical frailty: Results from the national center for geriatrics and gerontology's study of geriatric syndromes. (2017)
  • Author(s): Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H.
  • Journal Title: Maturitas Volume: 97 Pages: 32-37
  • DOI: 10.1016/j.maturitas.2016.12.005
  • Peer Reviewed
• [Journal Article] Driving and Incidence of Functional Limitation in Older People: A Prospective Population-Based Study. (2016)
  • Author(s): Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Doi T.
  • Journal Title: Gerontology Volume: 62(6) Issue: 6 Pages: 636-643
  • DOI: 10.1159/000448036
  • Peer Reviewed
• [Journal Article] Comorbid mild cognitive impairment and depressive symptoms predict future dementia in community older adults: a 24-month follow-up longitudinal study. (2016)
  • Author(s): Makizako H, Shimada H, Doi T, Tsutsumimoto K, Hotta R, Nakakubo S, Makino K, Suzuki T.
  • Journal Title: J Alzheimers Dis Volume: 54 Issue: 4 Pages: 1473-1482
  • DOI: 10.3233/jad-160244
  • Peer Reviewed / Open Access
• [Journal Article] Sleep Duration and Excessive Daytime Sleepiness Are Associated With Incidence of Disability in Community-Dwelling Older Adults. (2016)
  • Author(s): Nakakubo S, Doi T, Makizako H, Tsutsumimoto K, Hotta R, Ono R, Suzuki T, Shimada H.
  • Journal Title: J Am Med Dir Assoc Volume: 17 Issue: 8 Pages: 768.e1-768.e5
  • DOI: 10.1016/j.jamda.2016.05.020
  • Peer Reviewed / Open Access
• [Journal Article] Combined Effect of Slow Gait Speed and Depressive Symptoms on Incident Disability in Older Adults. (2016)
  • Author(s): Tsutsumimoto K, Doi T, Shimada H, Makizako H, Hotta R, Nakakubo S, Suzuki T
  • Journal Title: J Am Med Dir Assoc Volume: 17 Issue: 2 Pages: 123-127
  • DOI: 10.1016/j.jamda.2015.08.012
  • Peer Reviewed
• [Journal Article] Set-Shifting Ability Is Associated with Gray Matter Volume in Older People with Mild Cognitive Impairment. (2015)
  • Author(s): Tsutsumimoto K, Makizako H, Shimada H, Doi T, Suzuki T.
  • Journal Title: Dement Geriatr Cogn Dis Extra Volume: 5 Issue: 3 Pages: 395-403
  • DOI: 10.1159/000438721
  • Peer Reviewed / Open Access
• [Presentation] sedentary timeの増加はうつ傾向に関連するか？ (2015)
  • Author(s): 堤本広大, 土井剛彦, 島田裕之, 牧迫飛雄馬, 中窪翔, 鈴木隆雄.
  • Organizer: 第57回日本老年医学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2015-06-17
• [Presentation] Which types of cognitive function are related to atrophy of the bilateral medial temporal areas? (2015)
  • Author(s): Shimada H, Doi T, Lee S, Makizako H, Tsutsumimoto K.
  • Organizer: Organization for Human Brain Mapping Conference
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2015-06-13
  • Int'l Joint Research
• [Presentation] 堤本広大, 土井剛彦, 牧迫飛雄馬, 堀田亮, 中窪翔, 李相侖, 李成喆, 裵成琉, 原田和弘, 原田健次, 島田裕之. 歩行速度低下とうつ傾向の組み合わせによって将来の要介護発生リスクが増大する ―大規模コホートによる 33 か月間の前向き調査― (2015)
  • Author(s): 堤本広大, 土井剛彦, 牧迫飛雄馬, 堀田亮, 中窪翔, 李相侖, 李成喆, 裵成琉, 原田和弘, 原田健次, 島田裕之
  • Organizer: 第50回日本理学療法学術大会
  • Place of Presentation: 東京
  • Year and Date: 2015-06-05
• [Book] フレイルの予防とリハビリテーション（ステップ2.フレイルを評価する 6.認知機能・心理検査とフレイル. 島田裕之（編）,） (2015)
  • Author(s): 堤本広大
  • Total Pages: 8
  • Publisher: 医歯薬出版
• [Book] 運動による脳の制御―認知症予防のための運動―（第4章 認知症予防を目的とした運動プログラムと効果, 4-1 有酸素運動の方法と効果. 島田裕之（編）） (2015)
  • Author(s): 堤本広大
  • Total Pages: 12
  • Publisher: 杏林書院
• [Book] 基礎からわかる軽度認知障害（MCI）―効果的な認知症予防を目指して（第7章 認知症予防へ向けた地域保健事業の実際 Ⅱ.認知症予防のための運動教室. 鈴木隆雄（監）, 島田裕之（編）） (2015)
  • Author(s): 堤本広大.
  • Total Pages: 9
  • Publisher: 医学書院