Development of a rat model of unilateral spatial neglect

Research Project

Project/Area Number	15K12611
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Rehabilitation science/Welfare engineering
Research Institution	Fujita Health University
Principal Investigator	Takeda Kotaro 藤田医科大学, 保健学研究科, 准教授 (50618733)
Co-Investigator(Kenkyū-buntansha)	宮坂裕之藤田医科大学, 医療科学部, 研究員 (00440686) Orand Abbas 藤田医科大学, 藤田記念七栗研究所, 助教 (10612591) 水谷謙明藤田医科大学, 共同利用研究推進施設, 講師 (30351068) 岡田泰昌独立行政法人国立病院機構村山医療センター(臨床研究部), 電気生理学研究室, 室長 (80160688)
Project Period (FY)	2015-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	半側空間無視 / DMSO / 細胞毒性 / モデル動物
Outline of Final Research Achievements	Unilateral Spatial Neglect (USN) is one of the cognitive dysfunctions after stroke and appears mainly as a symptom that neglects the left side after cerebrovascular disease in the right hemisphere. For a more consistent basic study of medications to treat the USN, animal models are still necessary. However, there is little way to assess the USN in rodent models. This study, therefore, we propose a system to evaluate the degree of USN from the behavior of the model rats. On the other hand, dimethyl sulfoxide (DMSO), which is an organic solvent frequently used in medication, may have toxicity to inhibit the rat behavior. Then, we also identified the safe dose range of DMSO.
Academic Significance and Societal Importance of the Research Achievements	半側空間無視（USN）は患者の日常生活活動を未自立レベルに留め在宅復帰を困難にさせる要因のひとつである．しかしヒトでは損傷部位がさまざまであり，症状も運動機能障害など多岐にわたる．そこで損傷部位を統一したモデル動物による検討が必要となるが，USNをはじめとした高次脳機能障害を評価できるシステムは殆ど報告されていない．そこで本研究では，モデル動物においてUSNを評価するシステムを提案する．