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Development and evolution in morphogenesis of human brain and skull

Research Project

Project/Area Number 15K12619
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Developmental mechanisms and the body works
Research InstitutionThe University of Tokyo

Principal Investigator

Taga Gentaro  東京大学, 大学院教育学研究科(教育学部), 教授 (00272477)

Co-Investigator(Kenkyū-buntansha) 松井 三枝  金沢大学, 国際基幹教育院, 教授 (70209485)
檀 一平太  中央大学, 理工学部, 教授 (20399380)
Co-Investigator(Renkei-kenkyūsha) HOMAE Fumitaka  首都大学東京, 人文科学研究科, 准教授 (20533417)
TSUZUKI Daisuke  首都大学東京, 人文科学研究科, 特任准教授 (50646346)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords脳 / 発達 / 進化 / 乳児 / 頭蓋 / 形態
Outline of Final Research Achievements

Landmark points of the brain and cranial morphology were extracted using magnetic resonance imaging (MRI) of the head of 16 human infants and children from 3 to 22 months old, and the changes in size and morphology during development were analyzed. The study revealed that (1) there is a large morphological variation in a specific region of the brain, (2) the skull grows anisotropically in the anterior-posterior and lateral directions, and (3) the relative positional relationship between the brain and the skull landmark points is stable, in the course of development. The possibility that the diversity of brain and skull morphology in development leads to the evolution of the brain was discussed.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016 2015 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] Macroanatomical landmarks featuring junctions of major sulci and fissures and scalp landmarks based on the international 10-10 system for analyzing lateral cortical development of infants2017

    • Author(s)
      D. Tsuzuki, F. Homae, G. Taga, H. Watanabe, M. Matsui, I. Dan
    • Journal Title

      Frontiers in Neuroscience

      Volume: 11 Pages: 394-394

    • DOI

      10.3389/fnins.2017.00394

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MinR 10/20 system: Quantitative and reproducible cranial landmark setting method for MRI based on minimum initial reference points2016

    • Author(s)
      Tsuzuki, D., Watanabe, H., Dan, I. & Taga, G.
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 264 Pages: 86-93

    • DOI

      10.1016/j.jneumeth.2016.02.024

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Human Brain and Behavioral Development: A Dynamical System’s View of Human Development from Morphogenesis of the Brain in Embryo to Emergence of Behaviors in Infants2018

    • Author(s)
      G. Taga
    • Organizer
      KLI Colloquia, Konrad Lorenz Institute for Evolution and Cognition Research
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dynamics of human brain and behavioral development2017

    • Author(s)
      G. Taga
    • Organizer
      Seminar, Paleontological Institute and Museum, University of Zurich
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小児脳MRIを対象とした頭表ランドマークと脳特徴点の対応に関する検討:代数的記述および幾何学的解析を用いて2017

    • Author(s)
      續木 大介・保前 文高・多賀 厳太郎・渡辺 はま・松井 三枝・檀 一平太
    • Organizer
      日本光脳機能イメージング学会第20回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト脳の形態と機能の発達2016

    • Author(s)
      多賀厳太郎
    • Organizer
      第17回南部コロキウム
    • Place of Presentation
      大阪大学
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 小児脳の MRI 構造画像における脳溝・脳回の形態分析2015

    • Author(s)
      續木 大介、多賀 厳太郎、保前 文高、中島 允丈、渡辺 はま、檀 一平太、松井 三枝
    • Organizer
      第20回認知神経科学会学術集会
    • Place of Presentation
      伊藤謝恩ホール、東京都文京区
    • Year and Date
      2015-08-08
    • Related Report
      2015 Research-status Report
  • [Remarks] 東京大学大学院教育学研究科発達脳科学研究室

    • URL

      http://dbsl.p.u-tokyo.ac.jp

    • Related Report
      2017 Annual Research Report
  • [Remarks] Developmental Brain Science Laboratory

    • URL

      http://dbsl.p.u-tokyo.ac.jp

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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