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Mechanism of fiber type maintenance and change in skeletal muscle fibers as multinucleated cells

Research Project

Project/Area Number 15K12665
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionThe University of Electro-Communications

Principal Investigator

KANO Yutaka  電気通信大学, 大学院情報理工学研究科, 教授 (90293133)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords多核細胞 / 細胞内輸送 / グルコース / 骨格筋 / バイオイメージング / 蛍光グルコース / 生体恒常性
Outline of Final Research Achievements

The purpose of this study was to elucidate the mechanism of intracellular substances and nuclear information sharing of skeletal muscle fibers (multinuclear cells). This study clarified the existence of an active transport system to keep the intracellular level of glucose constant, and the existence of a mechanism to homogenize specific protein expression in the cell. As future research, it is necessary to elucidate the system that controls the mechanism by which skeletal muscle fibers retain uniform traits.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results) Presentation (1 results) Remarks (1 results)

  • [Int'l Joint Research] カンザス州立大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] カンザス州立大学(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Kansas State University(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Improved skeletal muscle Ca2+ regulation in vivo following contractions in mice overexpressing PGC-1α.2017

    • Author(s)
      Eshima, H., Miura, S., Senoo, N., Hatakeyama, K., Poole, D.C., and Kano, Y.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 印刷中 Issue: 6 Pages: 1017-1028

    • DOI

      10.1152/ajpregu.00032.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] pH buffering of single rat skeletal muscle fibers in the in vivo environment.2016

    • Author(s)
      Yoshinori Tanaka, Tadakatsu Inagaki, David C. Poole and Yutaka Kano.
    • Journal Title

      American Journal of Physiology - Regulatory, Integrative and Comparative Physiology.

      Volume: in press Issue: 10 Pages: R926-R933

    • DOI

      10.1152/ajpregu.00501.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 骨格筋細胞内におけるグルコース特異的な拡散動態2017

    • Author(s)
      小泉 柾夫,狩野 豊
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 電気通信大学 狩野研究室ホームページ

    • URL

      http://www.ecc.es.uec.ac.jp/index.html

    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2022-06-07  

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