Mechanism of fiber type maintenance and change in skeletal muscle fibers as multinucleated cells
| Project/Area Number |
15K12665
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | The University of Electro-Communications |
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Principal Investigator |
KANO Yutaka 電気通信大学, 大学院情報理工学研究科, 教授 (90293133)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 多核細胞 / 細胞内輸送 / グルコース / 骨格筋 / バイオイメージング / 蛍光グルコース / 生体恒常性 |
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| Outline of Final Research Achievements |
The purpose of this study was to elucidate the mechanism of intracellular substances and nuclear information sharing of skeletal muscle fibers (multinuclear cells). This study clarified the existence of an active transport system to keep the intracellular level of glucose constant, and the existence of a mechanism to homogenize specific protein expression in the cell. As future research, it is necessary to elucidate the system that controls the mechanism by which skeletal muscle fibers retain uniform traits.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Improved skeletal muscle Ca2+ regulation in vivo following contractions in mice overexpressing PGC-1α.2017
Author(s)
Eshima, H., Miura, S., Senoo, N., Hatakeyama, K., Poole, D.C., and Kano, Y.
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Journal Title
Am J Physiol Regul Integr Comp Physiol
Volume: 印刷中
Issue: 6
Pages: 1017-1028
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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