New mechanism of mitochondrial biogenesis mediated by nutritional substrate in skeletal muscle
| Project/Area Number |
15K12666
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
Masuda Kazumi 金沢大学, 人間科学系, 教授 (50323283)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAKAKURA HISASHI 同志社大学, スポーツ健康科学部, 助教 (20631914)
HASHIMOTO TAKESHI 立命館大学, スポーツ健康科学部, 教授 (70511608)
IWANAKA NOBUMASA 立命館大学, グローバルイノベーション研究機構, 研究員 (80584002)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 筋細胞 / 代謝 / ミトコンドリア / 基質 / シグナル |
|---|
| Outline of Final Research Achievements |
Mitochondrial biogenesis in response to exercise is reliant on adaptive changes through potentially key signal for activating mitochondrial biogenesis (eg. activation of SIRT1, AMPK and PGC-1a). Polyphenol curcumin is a natural antioxidant exhibiting a variety of pharmacological activities and therapeutic properties. However, it remains unknown the effect of curcumin and underlying mechanism on skeletal muscle for regulation of mitochondrial biogenesis. The purpose of the present study was to examine the effects of endurance training (eTR) and curcumin treatment on mitochondrial biogenesis and to identify some of key cascade along the cell signaling. The experimental results suggested that that curcumin treatment with eTR regulated mitochondria biogenesis in skeletal muscle through SIRT1 and AMPK -mediated signaling pathway.
|
Report
(4 results)
Research Products
(13 results)
