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Regulation of arterial blood pressure during exercise -contribution of aortic arch baroreflex-

Research Project

Project/Area Number 15K12672
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionMeiji University

Principal Investigator

Ichinose Masashi  明治大学, 経営学部, 専任教授 (10551476)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords循環調節 / 動脈血圧 / 圧受容器反射 / 心拍数 / 運動 / スポーツ生理学 / 血圧 / 動脈圧受容器反射 / 末梢反射
Outline of Final Research Achievements

The purpose of this study was to investigate the function of aortic arch baroreflex in cardiovascular regulation during exercise in humans. In the present study, 1) we developed an experimental model that noninvasively assesses the function of aortic arc baroreflex in humans. 2) Using this experimental model, we revealed that the aortic arch baroreflex plays a major role in tachycardiac response to acute reduction in arterial blood pressure both at rest and during exercise. The results of this study contribute to elucidate the mechanisms of arterial blood pressure regulation during exercise and will be an important scientific knowledge for considering safety of exercise and effectiveness of exercise training for promoting health and/or improving exercise performance.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 2015

All Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 4 results) Presentation (12 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results)

  • [Journal Article] Sympathoexcitation constrains vasodilation in the human skeletal muscle microvasculature during post-occlusive reactive hyperemia.2018

    • Author(s)
      Ichinose M, Nakabayashi M, Ono Y.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: In press Issue: 2 Pages: H242-H253

    • DOI

      10.1152/ajpheart.00010.2018

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Voluntary apnea during dynamic exercise activates the muscle metaboreflex in humans.2018

    • Author(s)
      Ichinose M, Matsumoto M, Fujii N, Yoshitake N, Nishiyasu T.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 314 Issue: 3 Pages: H434-H442

    • DOI

      10.1152/ajpheart.00367.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] トレーニング適応と血圧調節-圧受容器反射と筋代謝受容器反射-2018

    • Author(s)
      一之瀬真志
    • Journal Title

      体育の科学

      Volume: 68 Pages: 279-285

    • Related Report
      2017 Annual Research Report
  • [Journal Article] The carotid baroreflex modifies the pressor threshold of the muscle metaboreflex in humans2017

    • Author(s)
      Masashi Ichinose, Tomoko Ichinose-Kuwahara, Kazuhito Watanabe, Narihiko Kondo, Takeshi Nishiyasu
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 313 Issue: 3 Pages: H650-H657

    • DOI

      10.1152/ajpheart.00816.2016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of forearm muscle metaboreceptors activation on sweating and cutaneous vascular responses during dynamic exercise2016

    • Author(s)
      Amano T, Ichinose M, Inoue Y, Nishiyasu T, Koga S, Kenny G, Kondo N
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 309 Issue: 11 Pages: 1332-1339

    • DOI

      10.1152/ajpregu.00545.2015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Increasing blood flow to exercising muscle attenuates systemic cardiovascular responses during dynamic exercise in humans.2015

    • Author(s)
      Ichinose M, Ichinose-Kuwahara T, Kondo N, Nishiyasu T.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 309 Issue: 10 Pages: R1234-R1242

    • DOI

      10.1152/ajpregu.00063.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cardiovascular responses to forearm muscle metaboreflex activation during hypercapnia in humans.2015

    • Author(s)
      Delliaux S, Ichinose M, Watanabe K, Fujii N, Nishiyasu T.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 309 Issue: 1 Pages: R43-R50

    • DOI

      10.1152/ajpregu.00402.2014

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Modulation of muscle metaboreceptor activation upon sweating and cutaneous vascular responses to rising core temperature in humans.2015

    • Author(s)
      Amano T, Ichinose M, Inoue Y, Nishiyasu T, Koga S, Kondo N.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 308 Issue: 12 Pages: 990-997

    • DOI

      10.1152/ajpregu.00005.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Reduction of venous return abolishes muscle metaboreflex-mediated rise in cardiac output in exercising humans2017

    • Author(s)
      Masashi Ichinose, Tomoko Ichinose, Takeshi Nishiyasu
    • Organizer
      The 17th International Conference on Environmental Ergonomics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 筋代謝受容器反射による心拍出量増加反応における静脈還流量の重要性2017

    • Author(s)
      一之瀬真志,一之瀬智子,西保 岳
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Importance of Venous Return for Muscle Metaboreflex-mediated Stroke Volume and Cardiac Output Responses2017

    • Author(s)
      Masashi Ichinose, Tomoko Ichinose and Takeshi Nishiyasu.
    • Organizer
      American College of Sports Medicine 64th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 非定常負荷運動に対する動脈圧受容器反射感受性の応答2016

    • Author(s)
      一之瀬 真志,一之瀬 智子,西保 岳
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 運動時の反射性循環調節‐圧受容器反射を中心に‐2016

    • Author(s)
      一之瀬 真志
    • Organizer
      第24回日本運動生理学会大会
    • Place of Presentation
      熊本県熊本市
    • Year and Date
      2016-07-23
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Dynamic Modulation of Spontaneous Cardiac Baroreflex Sensitivity to Changes in Workloads in Humans2016

    • Author(s)
      Masashi Ichinose, Tomoko Ichinose, Takeshi Nishiyasu.
    • Organizer
      American College of Sports Medicine 63rd Annual Meeting
    • Place of Presentation
      Boston, Massachusetts USA.
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 頸動脈圧受容器反射が筋代謝受容器反射の昇圧閾値に及ぼす影響2015

    • Author(s)
      一之瀬真志,一之瀬智子,渡邊和仁,西保 岳
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県和歌山市
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] ハンドグリップ運動時における血圧上昇要因の個人差:運動様式の違いに着目して2015

    • Author(s)
      渡邊和仁,一之瀬真志,辻 文,前田清司,西保 岳
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県和歌山市
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 前腕部における筋代謝受容器活動が自転車運動時の熱放散反応に及ぼす影響2015

    • Author(s)
      天野達郎,一之瀬真志,井上芳光,西保 岳,近藤徳彦
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県和歌山市
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Pressor threshold of muscle metaboreflex is modulated during unloading of carotid baroreceptors in humans.2015

    • Author(s)
      Ichinose M, Ichinose-Kuwahara T, Watanabe K, Nishiyasu T.
    • Organizer
      16th International Conference on Environmental Ergonomics
    • Place of Presentation
      Portsmouth, UK
    • Year and Date
      2015-06-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Carotid Baroreflex Modifies Pressor Threshold of Muscle Metaboreflex in Humans.2015

    • Author(s)
      Ichinose M, Ichinose-Kuwahara T, Watanabe K, Nishiyasu T.
    • Organizer
      62nd American College of Sports Medicine annual meeting
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Time-Dependent Changes in Individual Differences in Components of the Pressor Responses to Isometric Handgrip Exercise.2015

    • Author(s)
      Watanabe K, Ichinose M, Tsuji B, Nishiyasu T.
    • Organizer
      62nd American College of Sports Medicine annual meeting
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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