Relationship between brain metabolism and exercise-induced improvement in brain function in human

• Project/Area Number: 15K12676
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Ritsumeikan University
• Principal Investigator: Hashimoto Takeshi 立命館大学, スポーツ健康科学部, 准教授 (70511608)
• Co-Investigator(Kenkyū-buntansha): 小河 繁彦 東洋大学, 理工学部, 教授 (80553841)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 実行機能 / 認知機能 / 脳 / 代謝 / 乳酸 / グルコース / 運動 / 脳内代謝 / 高強度間欠的運動

Outline of Final Research Achievements

This study was conducted to determine the relationship between brain metabolism and brain function (e.g., executive function) during exercise in human. It is suggested that alterations in exercise-induced systemic lactate levels affect brain lactate uptake, thereby influencing executive function.

Research Products

• [Int'l Joint Research] University of Copenhagen(デンマーク)
• [Journal Article] Impact of exercise intensity and duration on postexercise executive function. (2017)
  • Author(s): Hayato Tsukamoto, Saki Takenaka, Tadashi Suga, Daichi Tanaka, Tatsuya Takeuchi, Takafumi Hamaoka, Tadao Isaka, Takeshi Hashimoto
  • Journal Title: Medicine & Science in Sports & Exercise. Volume: 49(4) Issue: 4 Pages: 774-784
  • DOI: 10.1249/mss.0000000000001155
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Carotid baroreflex function at the onset of cycling in men. (2016)
  • Author(s): Barbosa TC, Vianna LC, Hashimoto T, Petersen LG, Olesen ND, Tsukamoto H, Sorensen H, Ogoh S, Nebrega AC, Secher NH.
  • Journal Title: American Journal of Physiology Volume: 311(5) Issue: 5 Pages: 870-878
  • DOI: 10.1152/ajpregu.00173.2016
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Myoglobin and the Regulation of Mitochondrial Respiratory Chain Complex IV (2016)
  • Author(s): Yamada T, Takakura H, Jue T, Hashimoto T, Ishizawa R, Furuichi Y, Kato Y, Iwanaka N, Masuda K
  • Journal Title: The Journal of Physiology Volume: 594 Issue: 2 Pages: 483-495
  • DOI: 10.1113/jp270824
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ultrasound tagged near infrared spectroscopy does not detect hyperventilation-induced reduction in cerebral blood flow (2016)
  • Author(s): Lund A, Secher NH, Hirasawa A, Ogoh S, Hashimoto T, Schytz HW, Ashina M, Sorensen H
  • Journal Title: The Scandinavian Journal of Clinical & Laboratory Investigation Volume: 76 Issue: 1 Pages: 82-87
  • DOI: 10.3109/00365513.2015.1101485
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Greater impact of acute high-intensity interval exercise on post-exercise executive function compared to moderate-intensity continuous exercise (2016)
  • Author(s): Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, and Hashimoto T
  • Journal Title: Physiology and Behavior Volume: 155 Pages: 224-230
  • DOI: 10.1016/j.physbeh.2015.12.021
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Repeated high-intensity interval exercise shortens the positive effect on executive function during post-exercise recovery in healthy young males (2016)
  • Author(s): Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, Ogoh S, and Hashimoto T
  • Journal Title: Physiology and Behavior Volume: 160 Pages: 26-34
  • DOI: 10.1016/j.physbeh.2016.03.029
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dehydroepiandrosterone activates AMP kinase and regulates GLUT4 and PGC-1α expression in C2C12 myotubes (2015)
  • Author(s): Yokokawa T, Sato K, Iwanaka N, Honda H, Higashida K, Iemitsu M, Hayashi T, Hashimoto T
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 463 Issue: 1-2 Pages: 42-47
  • DOI: 10.1016/j.bbrc.2015.05.013
  • Peer Reviewed
• [Journal Article] Specific characterization of regional storage fat in upper and lower limbs of young healthy adults (2015)
  • Author(s): Junichiro Yamauchi, Toshiyuki Kurihara, Maki Yoshikawa, Sadayoshi Taguchi, Takeshi Hashimoto
  • Journal Title: Springer Plus Volume: 4 Issue: 1 Pages: 402-402
  • DOI: 10.1186/s40064-015-1181-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] A combination of dynamic exercise and flavanol-rich cocoa consumption additively improve executive function in human (2016)
  • Author(s): Tsukamoto H, Suga T, Ishibashi A, Takenaka S, Goto K, Ebi K, Isaka T, and Hashimoto T
  • Organizer: 21th European College of Sport Science
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-07-06
  • Int'l Joint Research
• [Presentation] 生体内における乳酸の役割 (2016)
  • Author(s): 橋本健志
  • Organizer: 第１６回日本抗加齢医学会総会
  • Place of Presentation: パシフィコ横浜、神奈川県横浜市
  • Year and Date: 2016-06-10
  • Invited
• [Presentation] The Impact Of Exercise-induced Lactate On Executive Function After High-intensity Interval Exercise In Humans (2016)
  • Author(s): Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka H, Isaka T, Ogoh S and Hashimoto T
  • Organizer: 63th American College of Sport Medicine
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-06-02
  • Int'l Joint Research
• [Presentation] Role Of Acute Moderate-intensity Dynamic Exercise Duration On Post-exercise Executive Function (2016)
  • Author(s): Takenaka S, Tsukamoto H, Suga T, Tanaka D, Takeuchi T, Hamaoka H, Isaka T, and Hashimoto T
  • Organizer: 63th American College of Sport Medicine
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-06-02
  • Int'l Joint Research
• [Presentation] Dynamics of the Carotid Baroreflex Function at the Onset of Leg Cycling (2016)
  • Author(s): Thales C. Barbosa, Lauro C. Vianna, Takeshi Hashimoto, Lonnie G. Petersen, Niels D. Olesen, Hayato Tsukamoto, Henrik Sorensen, Shigehiko Ogoh, Antonio C. L. Nobrega, Niels H. Secher
  • Organizer: Experimental Biology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-04-05
  • Int'l Joint Research
• [Presentation] Dehydroepiandrosterone activates 5’-adenosine monophosphate-activated protein kinase and suppresses adipogenesis in 3T3-L1 cells. (2015)
  • Author(s): Yokokawa T, Sato K, Narusawa R, Kido K, Mori R, Iwanaka N, Hayashi T, Hashimoto T
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-03
• [Presentation] Lactate-based compound containing caffeine supplementation effectively decreases fat mass in middle-aged Japanese women (2015)
  • Author(s): Hashimoto T, Kurihara T, Homma T, Yoshikawa M, Narusawa R, Shimazu M, Uchida K, Kawasaki M, Tomi H, Hamaoka T
  • Organizer: Obesityweek 2015
  • Place of Presentation: Los Angels, USA
  • Year and Date: 2015-11-05
• [Presentation] 乳酸主体の飲用物が脂肪分解関連タンパク質発現に及ぼす影響の解析 (2015)
  • Author(s): 成澤諒子、横川拓海、東田一彦、橋本健志
  • Organizer: 日本体力医学会
  • Place of Presentation: 和歌山県民文化会館（和歌山県和歌山市）
  • Year and Date: 2015-09-20
• [Presentation] テオフィリンがC2C12骨格筋細胞における糖・脂質代謝関連遺伝子発現に及ぼす影響 (2015)
  • Author(s): 大崎智彦、横川拓海、木戸康平、岩中伸壮、橋本健志
  • Organizer: 日本体力医学会
  • Place of Presentation: 和歌山県民文化会館（和歌山県和歌山市）
  • Year and Date: 2015-09-20
• [Presentation] C2C12骨格筋細胞において、カルシウムシグナルならびにAMP kinaseがPGC-1 related coactivatorの遺伝子発現に及ぼす影響の検討 (2015)
  • Author(s): 横川拓海、大崎智彦、岩中伸壮、林達也、橋本健志
  • Organizer: 日本体力医学会
  • Place of Presentation: 和歌山県民文化会館（和歌山県和歌山市）
  • Year and Date: 2015-09-20
• [Presentation] 運動による乳酸産生量と実行機能亢進の関係性 (2015)
  • Author(s): 塚本敏人，菅唯志，武中沙葵，田中大智，伊坂忠夫，小河繁彦，橋本健志
  • Organizer: 日本体力医学会
  • Place of Presentation: 和歌山県民文化会館（和歌山県和歌山市）
  • Year and Date: 2015-09-19
• [Presentation] 運動後の実行機能亢進を持続させるための最適な運動実施時間の検討 (2015)
  • Author(s): 武中沙葵, 塚本敏人, 菅唯志，田中大智, 浜岡隆文, 伊坂忠夫, 橋本健志
  • Organizer: 日本体力医学会
  • Place of Presentation: 和歌山県民文化会館（和歌山県和歌山市）
  • Year and Date: 2015-09-19
• [Presentation] 運動後認知機能亢進に及ぼす運動と音楽の併用効果の検討 (2015)
  • Author(s): 田中大智，菅 唯志，塚本敏人，武中沙葵，浜岡隆文，橋本健志，伊坂忠夫
  • Organizer: 日本体力医学会
  • Place of Presentation: 和歌山県民文化会館（和歌山県和歌山市）
  • Year and Date: 2015-09-19
• [Presentation] 運動前のココア飲料摂取が高次脳機能に与える影響 (2015)
  • Author(s): 塚本 敏人，菅 唯志，石橋 彩，武中 沙葵，後藤 一成，海老 久美子，伊坂 忠夫，橋本 健志
  • Organizer: 第2回日本スポーツ栄養学会
  • Place of Presentation: 立命館大学（滋賀県草津市）
  • Year and Date: 2015-07-05
• [Presentation] Local resistance exercise improves cognitive executive function in a dose-dependent manner. (2015)
  • Author(s): Tsukamoto H, Suga T, Takenaka S, Takeuchi T, Tanaka D, Hamaoka T, Isaka T, and Hashimoto T
  • Organizer: Brain&Brain PET - ISCBFM
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2015-06-28
  • Int'l Joint Research
• [Presentation] Effect of lactoferrin on lipolytic activity upon catecholamine stimulation in 3T3-L1 adipocytes (2015)
  • Author(s): Sakamoto S, Ono T, Murakoshi M, and Hashimoto T
  • Organizer: 20th European College of Sport Science
  • Place of Presentation: Malmo, Sweden
  • Year and Date: 2015-06-24
  • Int'l Joint Research
• [Presentation] The effect of high-intensity interval exercise and moderate-intensity continuous exercise on executive function in post-exercise recovery (2015)
  • Author(s): Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, and Hashimoto T
  • Organizer: 20th European College of Sport Science
  • Place of Presentation: Malmo, Sweden
  • Year and Date: 2015-06-24
  • Int'l Joint Research
• [Presentation] Ambient Particular Matter (pm) Exposure Deteriorates Pulmonary Function in Early Childhood in Shanghai, China (2015)
  • Author(s): Taguchi S, Otsuka M, Suzuki K, Yamasaki S, Kitagawa K, Yin X-J, Ji L, Zhou Y-R, Liu X, and Hashimoto T
  • Organizer: 62th American College of Sport Medicine
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-05-29
  • Int'l Joint Research
• [Presentation] 神経細胞においてp38 MAPKおよびcAMP シグナルはPGC-1 familyの発現を制御する (2015)
  • Author(s): Yokokawa T, Morimura N, Mishina M, Fujita T, Tanaka H, Hayashi T, Hashimoto T
  • Organizer: 第62回日本生化学会近畿支部例会
  • Place of Presentation: 立命館大学（滋賀県草津市）
  • Year and Date: 2015-05-16
• [Book] 運動の健康への効用について (2016)
  • Author(s): 塚本敏人、橋本健志
  • Total Pages: 120
  • Publisher: 自動車技術
• [Book] 「運動によるミトコンドリア活性化：乳酸の役割」 アンチ・エイジング医学─日本抗加齢医学会雑誌 (2015)
  • Author(s): 橋本健志
  • Total Pages: 139
  • Publisher: 株）メディカルレビュー社
• [Remarks] スポーツ健康科学部ニュース一覧
  • URL: http://www.ritsumei.ac.jp/shs/news/article.html/?id=216
• [Remarks] スポーツ健康科学部ニュース一覧
  • URL: http://www.ritsumei.ac.jp/shs/news/article.html/?id=193