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Relationship between brain metabolism and exercise-induced improvement in brain function in human

Research Project

Project/Area Number 15K12676
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionRitsumeikan University

Principal Investigator

Hashimoto Takeshi  立命館大学, スポーツ健康科学部, 准教授 (70511608)

Co-Investigator(Kenkyū-buntansha) 小河 繁彦  東洋大学, 理工学部, 教授 (80553841)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords実行機能 / 認知機能 / 脳 / 代謝 / 乳酸 / グルコース / 運動 / 脳内代謝 / 高強度間欠的運動
Outline of Final Research Achievements

This study was conducted to determine the relationship between brain metabolism and brain function (e.g., executive function) during exercise in human. It is suggested that alterations in exercise-induced systemic lactate levels affect brain lactate uptake, thereby influencing executive function.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (32 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 3 results,  Open Access: 3 results) Presentation (19 results) (of which Int'l Joint Research: 8 results,  Invited: 1 results) Book (2 results) Remarks (2 results)

  • [Int'l Joint Research] University of Copenhagen(デンマーク)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Impact of exercise intensity and duration on postexercise executive function.2017

    • Author(s)
      Hayato Tsukamoto, Saki Takenaka, Tadashi Suga, Daichi Tanaka, Tatsuya Takeuchi, Takafumi Hamaoka, Tadao Isaka, Takeshi Hashimoto
    • Journal Title

      Medicine & Science in Sports & Exercise.

      Volume: 49(4) Issue: 4 Pages: 774-784

    • DOI

      10.1249/mss.0000000000001155

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Carotid baroreflex function at the onset of cycling in men.2016

    • Author(s)
      Barbosa TC, Vianna LC, Hashimoto T, Petersen LG, Olesen ND, Tsukamoto H, Sorensen H, Ogoh S, Nebrega AC, Secher NH.
    • Journal Title

      American Journal of Physiology

      Volume: 311(5) Issue: 5 Pages: 870-878

    • DOI

      10.1152/ajpregu.00173.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Myoglobin and the Regulation of Mitochondrial Respiratory Chain Complex IV2016

    • Author(s)
      Yamada T, Takakura H, Jue T, Hashimoto T, Ishizawa R, Furuichi Y, Kato Y, Iwanaka N, Masuda K
    • Journal Title

      The Journal of Physiology

      Volume: 594 Issue: 2 Pages: 483-495

    • DOI

      10.1113/jp270824

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ultrasound tagged near infrared spectroscopy does not detect hyperventilation-induced reduction in cerebral blood flow2016

    • Author(s)
      Lund A, Secher NH, Hirasawa A, Ogoh S, Hashimoto T, Schytz HW, Ashina M, Sorensen H
    • Journal Title

      The Scandinavian Journal of Clinical & Laboratory Investigation

      Volume: 76 Issue: 1 Pages: 82-87

    • DOI

      10.3109/00365513.2015.1101485

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Greater impact of acute high-intensity interval exercise on post-exercise executive function compared to moderate-intensity continuous exercise2016

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, and Hashimoto T
    • Journal Title

      Physiology and Behavior

      Volume: 155 Pages: 224-230

    • DOI

      10.1016/j.physbeh.2015.12.021

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Repeated high-intensity interval exercise shortens the positive effect on executive function during post-exercise recovery in healthy young males2016

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, Ogoh S, and Hashimoto T
    • Journal Title

      Physiology and Behavior

      Volume: 160 Pages: 26-34

    • DOI

      10.1016/j.physbeh.2016.03.029

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dehydroepiandrosterone activates AMP kinase and regulates GLUT4 and PGC-1α expression in C2C12 myotubes2015

    • Author(s)
      Yokokawa T, Sato K, Iwanaka N, Honda H, Higashida K, Iemitsu M, Hayashi T, Hashimoto T
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 463 Issue: 1-2 Pages: 42-47

    • DOI

      10.1016/j.bbrc.2015.05.013

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Specific characterization of regional storage fat in upper and lower limbs of young healthy adults2015

    • Author(s)
      Junichiro Yamauchi, Toshiyuki Kurihara, Maki Yoshikawa, Sadayoshi Taguchi, Takeshi Hashimoto
    • Journal Title

      Springer Plus

      Volume: 4 Issue: 1 Pages: 402-402

    • DOI

      10.1186/s40064-015-1181-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] A combination of dynamic exercise and flavanol-rich cocoa consumption additively improve executive function in human2016

    • Author(s)
      Tsukamoto H, Suga T, Ishibashi A, Takenaka S, Goto K, Ebi K, Isaka T, and Hashimoto T
    • Organizer
      21th European College of Sport Science
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体内における乳酸の役割2016

    • Author(s)
      橋本健志
    • Organizer
      第16回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The Impact Of Exercise-induced Lactate On Executive Function After High-intensity Interval Exercise In Humans2016

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka H, Isaka T, Ogoh S and Hashimoto T
    • Organizer
      63th American College of Sport Medicine
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-06-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role Of Acute Moderate-intensity Dynamic Exercise Duration On Post-exercise Executive Function2016

    • Author(s)
      Takenaka S, Tsukamoto H, Suga T, Tanaka D, Takeuchi T, Hamaoka H, Isaka T, and Hashimoto T
    • Organizer
      63th American College of Sport Medicine
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-06-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamics of the Carotid Baroreflex Function at the Onset of Leg Cycling2016

    • Author(s)
      Thales C. Barbosa, Lauro C. Vianna, Takeshi Hashimoto, Lonnie G. Petersen, Niels D. Olesen, Hayato Tsukamoto, Henrik Sorensen, Shigehiko Ogoh, Antonio C. L. Nobrega, Niels H. Secher
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-04-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dehydroepiandrosterone activates 5’-adenosine monophosphate-activated protein kinase and suppresses adipogenesis in 3T3-L1 cells.2015

    • Author(s)
      Yokokawa T, Sato K, Narusawa R, Kido K, Mori R, Iwanaka N, Hayashi T, Hashimoto T
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Lactate-based compound containing caffeine supplementation effectively decreases fat mass in middle-aged Japanese women2015

    • Author(s)
      Hashimoto T, Kurihara T, Homma T, Yoshikawa M, Narusawa R, Shimazu M, Uchida K, Kawasaki M, Tomi H, Hamaoka T
    • Organizer
      Obesityweek 2015
    • Place of Presentation
      Los Angels, USA
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 乳酸主体の飲用物が脂肪分解関連タンパク質発現に及ぼす影響の解析2015

    • Author(s)
      成澤諒子、横川拓海、東田一彦、橋本健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館(和歌山県和歌山市)
    • Year and Date
      2015-09-20
    • Related Report
      2015 Research-status Report
  • [Presentation] テオフィリンがC2C12骨格筋細胞における糖・脂質代謝関連遺伝子発現に及ぼす影響2015

    • Author(s)
      大崎智彦、横川拓海、木戸康平、岩中伸壮、橋本健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館(和歌山県和歌山市)
    • Year and Date
      2015-09-20
    • Related Report
      2015 Research-status Report
  • [Presentation] C2C12骨格筋細胞において、カルシウムシグナルならびにAMP kinaseがPGC-1 related coactivatorの遺伝子発現に及ぼす影響の検討2015

    • Author(s)
      横川拓海、大崎智彦、岩中伸壮、林達也、橋本健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館(和歌山県和歌山市)
    • Year and Date
      2015-09-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 運動による乳酸産生量と実行機能亢進の関係性2015

    • Author(s)
      塚本敏人,菅唯志,武中沙葵,田中大智,伊坂忠夫,小河繁彦,橋本健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館(和歌山県和歌山市)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 運動後の実行機能亢進を持続させるための最適な運動実施時間の検討2015

    • Author(s)
      武中沙葵, 塚本敏人, 菅唯志,田中大智, 浜岡隆文, 伊坂忠夫, 橋本健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館(和歌山県和歌山市)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 運動後認知機能亢進に及ぼす運動と音楽の併用効果の検討2015

    • Author(s)
      田中大智,菅 唯志,塚本敏人,武中沙葵,浜岡隆文,橋本健志,伊坂忠夫
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館(和歌山県和歌山市)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 運動前のココア飲料摂取が高次脳機能に与える影響2015

    • Author(s)
      塚本 敏人,菅 唯志,石橋 彩,武中 沙葵,後藤 一成,海老 久美子,伊坂 忠夫,橋本 健志
    • Organizer
      第2回日本スポーツ栄養学会
    • Place of Presentation
      立命館大学(滋賀県草津市)
    • Year and Date
      2015-07-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Local resistance exercise improves cognitive executive function in a dose-dependent manner.2015

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Takeuchi T, Tanaka D, Hamaoka T, Isaka T, and Hashimoto T
    • Organizer
      Brain&Brain PET - ISCBFM
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2015-06-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of lactoferrin on lipolytic activity upon catecholamine stimulation in 3T3-L1 adipocytes2015

    • Author(s)
      Sakamoto S, Ono T, Murakoshi M, and Hashimoto T
    • Organizer
      20th European College of Sport Science
    • Place of Presentation
      Malmo, Sweden
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of high-intensity interval exercise and moderate-intensity continuous exercise on executive function in post-exercise recovery2015

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, and Hashimoto T
    • Organizer
      20th European College of Sport Science
    • Place of Presentation
      Malmo, Sweden
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Ambient Particular Matter (pm) Exposure Deteriorates Pulmonary Function in Early Childhood in Shanghai, China2015

    • Author(s)
      Taguchi S, Otsuka M, Suzuki K, Yamasaki S, Kitagawa K, Yin X-J, Ji L, Zhou Y-R, Liu X, and Hashimoto T
    • Organizer
      62th American College of Sport Medicine
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経細胞においてp38 MAPKおよびcAMP シグナルはPGC-1 familyの発現を制御する2015

    • Author(s)
      Yokokawa T, Morimura N, Mishina M, Fujita T, Tanaka H, Hayashi T, Hashimoto T
    • Organizer
      第62回日本生化学会近畿支部例会
    • Place of Presentation
      立命館大学(滋賀県草津市)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Research-status Report
  • [Book] 運動の健康への効用について2016

    • Author(s)
      塚本敏人、橋本健志
    • Total Pages
      120
    • Publisher
      自動車技術
    • Related Report
      2016 Annual Research Report
  • [Book] 「運動によるミトコンドリア活性化:乳酸の役割」 アンチ・エイジング医学─日本抗加齢医学会雑誌2015

    • Author(s)
      橋本健志
    • Total Pages
      139
    • Publisher
      株)メディカルレビュー社
    • Related Report
      2015 Research-status Report
  • [Remarks] スポーツ健康科学部ニュース一覧

    • URL

      http://www.ritsumei.ac.jp/shs/news/article.html/?id=216

    • Related Report
      2015 Research-status Report
  • [Remarks] スポーツ健康科学部ニュース一覧

    • URL

      http://www.ritsumei.ac.jp/shs/news/article.html/?id=193

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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