Migration of mitochondria and nuclei in cell culture

Research Project

Project/Area Number	15K12677
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Sports science
Research Institution	Fukuoka University
Principal Investigator	Higaki Yasuki 福岡大学, スポーツ科学部, 教授 (10228702)
Co-Investigator(Kenkyū-buntansha)	須藤みず紀公益財団法人明治安田厚生事業団体力医学研究所, その他部局等, 研究員(移行) (10585186) 兼岡秀俊福岡大学, 医学部, 教授 (20161169) 安藤創一電気通信大学, 大学院情報理工学研究科, 准教授 (50535630) 安野哲彦福岡大学, 医学部, 講師 (80551994)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	ミトコンドリア / グリコーゲン / 核
Outline of Final Research Achievements	Insulin resistance is associated with high levels of stored lipids in skeletal muscle cells. Fat storage in skeletal muscle from endurance athlete is higher than that in obese people. However, it is not clear why enhanced insulin sensitivity is observed in endurance athletes who had high lipid storage in skeletal muscle. In this study we observed that mitochondria and lipid droplet are existed around nucleus, and nucleus and mitochondria go around lipid droplet in human induced pluripotent stem cells-derived myocytes. We speculate that localization of mitochondria and lipid droplet in skeletal muscle cells may be associated with insulin resistance.