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Identification of substances in vivo that increase virus growth in a healthy human body

Research Project

Project/Area Number 15K12680
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionOkayama University

Principal Investigator

Arao Yujiro  岡山大学, 保健学研究科, 教授 (40151146)

Research Collaborator KANEYUKI Masumi  
MIYAZAKI Makoto  
SAKURAI Sae  
TSUJI Hiroki  
MATSUMOTO Kaho  
TAKIZAWA Emi  
ABE Mizuki  
TAKADA Haruka  
MURAYAMA Chisa  
WATANABE Taiga  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords健常人 / 唾液 / 持続感染ウイルス / トルケテノウイルス / ヒトヘルペスウイルス6型 / nested real-time PCR / 炎症関連因子 / ストレス応答因子
Outline of Final Research Achievements

I tried to obtain clues to prevent the onset and advancing in severity of viral diseases. I collected saliva at rest from three healthy young adult subjects as specimens. I quantified Torque teno virus (TTV) DNA, human herpesvirus type 6 (HHV 6) DNA, inflammation-related factors, and stress-responsive factors in these specimens and then, searched host factors correlated with TTV or HHV6 DNA.
In one subject, there was a negative correlation between TTV DNA and alpha-amylase and there were weak negative correlations between TTV DNA and both secretory IgA and estradiol. In two of three subjects, I found weak negative correlations between the three substances in vivo and TTV DNA. Thus, it was speculated that the substances are likely to be associated with TTV DNA excreted in healthy human saliva.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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