Analysis of T cells in immunological aging
| Project/Area Number |
15K12694
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
TACHIKAWA AI 国立感染症研究所, エイズ研究センター, 室長 (10396880)
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| Research Collaborator |
SATO Hidenori 東京大学, 医科学研究所, 大学院生
TACHIKAWA Natsuo 横浜市立市民病院, 感染症科, 科長
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 免疫老化 / 慢性ウイルス感染症 / T細胞 / HIV感染症 / T細胞応答 / 持続感染 |
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| Outline of Final Research Achievements |
Biological aging results in functional decline in immune system, accompanied by increase in severity of infectious diseases. It is revealed that most diseases become problematic in aged people are related to immunological disorder. It also become widely known that immunological character in chronic HIV-infected subjects is consistent with that seen in elderly people, called “immunosenescence”. In this study, we characterized T cells in chronic HIV-infected subjects, and the expression of molecular markers related to senescence were significantly higher in early differentiated T cells compared to HIV-uninfected age-matched subjects. We also performed gene expression analysis after antigen stimulation, and genes critical for T cell function were induced excessively compared to HIV-uninfected subjects. These data suggest that T cells, especially in early-differentiated subsets that are normally in quiescent state, are in a state “easy-to-activate” in response to antigen stimulation.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Rapid HIV-1 disease progression in individuals infected with a virus adapted to its host population.2016
Author(s)
Katoh J, Kawana-Tachikawa A, Shimizu A, Zhu D, Han C, Nakamura H, Koga M, Kikuchi T, Adachi E, Koibuchi T, Gao GF, Brumme ZL, Iwamoto A.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Association between a naturally arising polymorphism within a functional region of HIV-1 Nef and disease progression in chronic HIV-1 infection.2015
Author(s)
Merlbe SC, Hasan Z, Mahiti M, Toyoda M, Mori M, Gatanaga H, Kikuchi T, Miura T, Kawana-Tachikawa A, Iwamoto A, Oka S, Ueno T.
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Journal Title
Archives of Virology
Volume: 160
Pages: 2033-2041
Related Report
Peer Reviewed
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[Journal Article] Anti-APOBEC3G Activity of HIV-1 Vif Protein Is Attenuated in Elite Controllers.2015
Author(s)
Kikuchi T, Iwabu Y, Tada T, Kawana-Tachikawa A, Koga M, Hosoya N, Nomura S, Brumme ZL, Jessen H, Pereyra F, Trocha A, Walker BD, Iwamoto A, Tokunaga K, Miura T.
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Journal Title
Journal of Virology
Volume: 89
Pages: 4992-5001
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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