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Analysis of T cells in immunological aging

Research Project

Project/Area Number 15K12694
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

TACHIKAWA AI  国立感染症研究所, エイズ研究センター, 室長 (10396880)

Research Collaborator SATO Hidenori  東京大学, 医科学研究所, 大学院生
TACHIKAWA Natsuo  横浜市立市民病院, 感染症科, 科長
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords免疫老化 / 慢性ウイルス感染症 / T細胞 / HIV感染症 / T細胞応答 / 持続感染
Outline of Final Research Achievements

Biological aging results in functional decline in immune system, accompanied by increase in severity of infectious diseases. It is revealed that most diseases become problematic in aged people are related to immunological disorder. It also become widely known that immunological character in chronic HIV-infected subjects is consistent with that seen in elderly people, called “immunosenescence”. In this study, we characterized T cells in chronic HIV-infected subjects, and the expression of molecular markers related to senescence were significantly higher in early differentiated T cells compared to HIV-uninfected age-matched subjects. We also performed gene expression analysis after antigen stimulation, and genes critical for T cell function were induced excessively compared to HIV-uninfected subjects. These data suggest that T cells, especially in early-differentiated subsets that are normally in quiescent state, are in a state “easy-to-activate” in response to antigen stimulation.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (2 results)

  • [Journal Article] Homeostatically Maintained Resting Naive CD4+ T Cells Resist Latent HIV Reactivation.2016

    • Author(s)
      Tsunetsugu-Yokota Y, Kobayahi-Ishihara M, Wada Y, Terahara K, Takeyama H, Kawana-Tachikawa A, Tokunaga K, Yamagishi M, Martinez JP, Meyerhans A.
    • Journal Title

      Front. Microbiol.

      Volume: 7 Pages: 1944-1944

    • DOI

      10.3389/fmicb.2016.01944

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Short intracellular HIV-1 transcripts as biomarkers of residual immune activation in patients on antiretroviral therapy.2016

    • Author(s)
      A. Ishizaka, H. Sato, H. Nakamura, M. Koga, T. Kikuchi, N. Hosoya, T. Koibuchi, A. Nomoto, A. Kawana-Tachikawa and T. Mizutani
    • Journal Title

      Journal of Virology

      Volume: 未確定 Issue: 12 Pages: 5665-76

    • DOI

      10.1128/jvi.03158-15

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Rapid HIV-1 disease progression in individuals infected with a virus adapted to its host population.2016

    • Author(s)
      Katoh J, Kawana-Tachikawa A, Shimizu A, Zhu D, Han C, Nakamura H, Koga M, Kikuchi T, Adachi E, Koibuchi T, Gao GF, Brumme ZL, Iwamoto A.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 3 Pages: e0150397-e0150397

    • DOI

      10.1371/journal.pone.0150397

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between a naturally arising polymorphism within a functional region of HIV-1 Nef and disease progression in chronic HIV-1 infection.2015

    • Author(s)
      Merlbe SC, Hasan Z, Mahiti M, Toyoda M, Mori M, Gatanaga H, Kikuchi T, Miura T, Kawana-Tachikawa A, Iwamoto A, Oka S, Ueno T.
    • Journal Title

      Archives of Virology

      Volume: 160 Pages: 2033-2041

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-APOBEC3G Activity of HIV-1 Vif Protein Is Attenuated in Elite Controllers.2015

    • Author(s)
      Kikuchi T, Iwabu Y, Tada T, Kawana-Tachikawa A, Koga M, Hosoya N, Nomura S, Brumme ZL, Jessen H, Pereyra F, Trocha A, Walker BD, Iwamoto A, Tokunaga K, Miura T.
    • Journal Title

      Journal of Virology

      Volume: 89 Issue: 9 Pages: 4992-5001

    • DOI

      10.1128/jvi.03464-14

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] HIV感染者における胃炎と腸管遊走性CD4陽性T細胞の検討.2016

    • Author(s)
      23.佐藤秀憲、大田泰徳、松原康朗、菊地正、古賀道子、鯉渕智彦、俣野哲朗、立川 愛、安達英輔
    • Organizer
      第30回日本エイズ学会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] iPS細胞技術を用いて作製したHIV特異的細胞傷害性Tリンパ球の解析.2016

    • Author(s)
      立川(川名)愛、河合洋平、金子新
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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