Intervention in fuel choice system for treatment of obesity
Project/Area Number |
15K12695
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied health science
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 内分泌学 / 代謝学 / 分子生物学 / FGF21 / アミノ酸 / 内科学 / 生活習慣病 / 糖尿病 / 内科 / エネルギー / 脂肪 / 肥満 / グルココルチコイド |
Outline of Final Research Achievements |
We clarified the physiological mechanism that selects the categories (lipids, proteins, carbohydrates) of body energy storage molecules consumed according to the situation inside and outside the individual, in particular the mechanism that regulates the amount of lipid mobilization. That is, using the FGF21 promoter reporter adenovirus system in the liver, we found that several amino acids are key signals by screening targeting FGF21 gene expression. The preventive and therapeutic effects of obesity and lifestyle diseases through preferential consumption of lipids were verified in animal models by human intervention such as amino acid antagonists targeting such physiological mechanisms.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5-/dim B-helper T cell induction2017
Author(s)
Toshiki Eri, Kimito Kawahata, Takeyuki Kanzaki, Mitsuru Imamura, Kazuya Michishita, Lisa Akahira, Ei Bannai, Noritada Yoshikawa, Yasumasa Kimura, Takeshi Satoh, Satoshi Uematsu, Hirotoshi Tanaka, and Kazuhiko Yamamoto
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Journal Article] The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure2017
Author(s)
Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 39752-39752
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The effects of bolus supplementation of branched-chain amino acids on skeletal muscle mass, strength, and function in patients with rheumatic disorders during glucocorticoid treatment2017
Author(s)
Yoshikawa N, Shimizu N, Uehara M, Oda Y, Matsumiya R, Matsubara E, Kobayashi H, Hosono O, Kuribara-Souta A, Baba H, Nagamura F, Kiryu S, Tanaka H
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Journal Title
Modern Rheumatology
Volume: 印刷中
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A Muscle-liver-fat signaling axis is essential for central control of adaptive adipose remodeling2015
Author(s)
Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, Tasaka Y, Kuribara-Souta A, Miyata K, Oike Y, Berger S, Schutz G, Takeda S & Tanaka H
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Journal Title
Nat Commun
Volume: -
Issue: 1
Pages: 6693-6693
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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