Nutritional Regulations of metabolic syndrome

• Project/Area Number: 15K12706
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Osaka City University
• Principal Investigator: SAEKI Shigeru 大阪市立大学, 大学院生活科学研究科, 教授 (60211926)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 栄養素 / メタボリック症候群 / 時計遺伝子

Outline of Final Research Achievements

The present studies elucidated that primary hepatocyte and established fibroblast cell line from rats with metabolic syndrome showed disorders in circadian rhythms of clock genes. Dietary proteins affected UCP1 and UCP2 mRNA expressions in brown adipose tissue that plays a significant role in energy expenditure. They also induced in abnormal circadian rhythms in hepatic Cyp7A1 mRNA expression.