| Project/Area Number |
15K12707
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Takasaki University of Health and Welfare |
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Principal Investigator |
Matsuoka Isao 高崎健康福祉大学, 薬学部, 教授 (10145633)
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 政明 高崎健康福祉大学, 薬学部, 助教 (30438759)
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| Research Collaborator |
Kazuki Yoshida
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 運動トレーニング / 骨格筋 / 糖取り込み / グルコース輸送体４ / ＡＴＰ / Ｐ２Ｙ２受容体 / 細胞外ＡＴＰ分解酵素 / ＡＭＰキナーゼ / Ａｋｔ / Ｒａｂ / TBC1D1 / ATP / P2Y2受容体 / 細胞外ATP分解酵素 |
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| Outline of Final Research Achievements |
Aerobic exercise has been shown to improve lifestyle-related diseases such as diabetes and hypertension, but its mechanism is not clear. In this study, we have demonstrated that ATP, an intracellular energy substance, was released from skeletal muscle during exercise, stimulated the G protein-coupled P2Y2 receptor in skeletal muscle cells and promoted glucose uptake as similar to insulin-induced effect. However, unlike the mechanism involved in insulin-induced effects (PI 3 kinase-Akt pathway), the action of ATP was mediated by AMP kinase activation, a pathway known to be stimulated in skeletal muscle during exercise. These results suggest that extracellular ATP increased during exercise, improves glucose tolerance via stimulation of specific receptor in a insulin-independent manner.
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