Micro-RNA analysis and birth cohort study for mothers and children in order to detect early diagnosis for autism spectrum disorders
Project/Area Number |
15K12720
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Childhood science (childhood environment science)
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Research Institution | University of Fukui |
Principal Investigator |
TOMODA AKEMI 福井大学, 子どものこころの発達研究センター, 教授 (80244135)
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Co-Investigator(Renkei-kenkyūsha) |
FUJISAWA TAKASHI 福井大学, 子どものこころの発達研究センター, 特命講師 (90434894)
SHIMADA KOJI 福井大学, 子どものこころの発達研究センター, 特命助教 (00711128)
KOSAKA HIROTAKA 福井大学, 子どものこころの発達研究センター, 教授 (70401966)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 自閉スペクトラム症(ASD) / マイクロRNA / バイオマーカー / 視線計測検出装置 / オキシトシン受容体(OXTR)遺伝子多型 / Gazefinder / 発達コホート調査 / 社会的情報 / Gazefinder® |
Outline of Final Research Achievements |
We investigated whether microRNAs is associated with features of high-functioning autism spectrum disorders(ASD).42 subjects with ASD and 127 age- and IQ-matched typically developing controls underwent blood sampling and their microRNAs were analyzed.Relative to TD controls,subjects with ASD showed significantly lower microRNAs expressions.We examined visual attention using an eye tracking system in infants(6-90 months of age)and measured the concentration of oxytocin(OT)in saliva samples.We observed a negative association between age and both attention toward social cues and salivary OT levels,and a positive association between age and attention for non-social cues.Our results suggest that there is an age-dependent association between visual attention for social cues and OT levels in infants and children, and that the development of visual attention to the eyes as social cues is associated with both OXTR polymorphisms and OT levels.These variations contribute to heterogeneity in ASD.
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Report
(3 results)
Research Products
(74 results)
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[Journal Article] Increased anterior pelvic angle characterizes the gait of children with attention deficit/hyperactivity disorder (ADHD).2017
Author(s)
Naruse H, Fujisawa TX, Yatsuga C, Kubota M, Matsuo H, Takiguchi S, Shimada S, Imai Y, Hiratani M, Kosaka H, Tomoda A*.
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Journal Title
PLoS One
Volume: 12(1)
Issue: 1
Pages: e0170096-e0170096
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial.2016
Author(s)
Kosaka H, Okamoto Y, Munesue T, Yamasue H, Inohara K, Fujioka T, Anme T, Orisaka M, Ishitobi M, Jung M, Fujisawa TX, Tanaka S, Arai S, Asano M, Saito DN, Sadato N, Tomoda A, Omori M, Sato M, Okazawa H, Higashida H, Wada Y.
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Journal Title
Translational Psychiatry
Volume: 6
Issue: 8
Pages: e872-e872
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome2016
Author(s)
Mizuno, K., Kawatani, J., Tajima, K., Sasaki, A. T., Yoneda, T., Komi, M., Hirai, T., Tomoda, A., Joudoi, T., Watanabe, Y.
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Journal Title
Neuroimage: Clinical, 12: 600-606, 2016.
Volume: 12
Pages: 600-606
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Decision making processes based on social conventional rules in early adolescents with and without autism spectrum disorders.2016
Author(s)
Komeda, H., Osanai, H., Yanaoka, K., Okamoto, Y., Fujioka, T., Arai, S., Inohara, K., Koyasu, M., Kusumi, T., Takiguchi, S., Kawatani, M., Kumazaki, H., Hiratani, M., Tomoda, A., & Kosaka, H.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 37875-37875
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Aripiprazole in the treatment of irritability in children and adolescents with autism spectrum disorder in Japan: A randomized, double-blind, placebo-controlled study.2016
Author(s)
Ichikawa H, Mikami K, Okada T, Yamashita Y, Ishizaki Y, Tomoda A, Ono H, Usuki C, Tadori Y.
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Journal Title
Child Psychiatry Hum Dev
Volume: 7(6)
Issue: 5
Pages: 841-851
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults.2016
Author(s)
Fujioka T, Inohara K, Okamoto Y, Masuya Y, Ishitobi M, Saito DN, Jung M, Arai S, Matsumura Y, Fujisawa TX, Narita K, Suzuki K, Tsuchiya JK, Mori N, Katayama T, Sato M, Munesue T, Okazawa H, Tomoda A, Wada Y, Kosaka H.
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Journal Title
Molecular Autism
Volume: 7
Issue: 1
Pages: 19-19
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Altered frontal pole development affects self-generated spatial working memory in ADHD.2015
Author(s)
Arai S, Okamoto Y, Fujioka T, Inohara K, Ishitobi M, Matsumura Y, Jung M, Kawamura K, Takiguchi S, Tomoda A, Wada Y, Hiratani M, Matsuura N, Kosaka H.
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Journal Title
Brain Dev
Volume: S0387-7606
Issue: 5
Pages: 00235-1
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The effect of oxytocin on detection of altruistic person for children.2016
Author(s)
Koizumi M, Matsumura Y, Ishikawa S, Matsumoto H, Masuya Y, Okazaki R, Okamoto Y, Fujioka T, Takiguchi S, Tomoda A, Kosaka H
Organizer
The 22nd International Association for Child and Adolescent Psychiatry and Allied Professions (IACAPAP) World Congress and the 36th CACAP Conference (
Place of Presentation
Calgary, Canada
Related Report
Int'l Joint Research
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[Presentation] The neural effects of intranasal oxytocin administration in reactive attachment disorder.2016
Author(s)
Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Shimada K, Okamoto Y, Nishikawa S, Takada S, Mizuno Y, Kosaka H, Tomoda A
Organizer
第58回日本小児神経学会学術総会
Place of Presentation
京王プラザホテル(東京都新宿区)
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[Presentation] Can Robotic Interaction Improve Nonverbal Communication and Social Anxiety of Children with Autism Spectrum Disorders?2015
Author(s)
Kumazaki H, Yoshikawa Y, Matsumoto Y, Mizushima S, Fujisawa T.X, Kosaka H, Tomoda A, Nemoto S, Nakano M, Miyao M, Maeda T, Ishiguro H, Muramatsu M, Mimura M.
Organizer
International Meeting for Autism Research (IMFAR) (ポスター発表)
Place of Presentation
Salt Lake City(USA)
Year and Date
2015-05-14
Related Report
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