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Paradigm shift of the mechanisms that development of higher brain function on maternofetal transmission

Research Project

Project/Area Number 15K12728
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Childhood science (childhood environment science)
Research InstitutionTokai University

Principal Investigator

TATEMICHI Masayuki  東海大学, 医学部, 教授 (00318263)

Co-Investigator(Kenkyū-buntansha) 遠藤 整  東海大学, 医学部, 講師 (10550551)
Research Collaborator ETO Tomoo  
OWADA Satoshi  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords母体環境 / THAラット / 学習 / 次世代影響 / 高学習能 / 母子間伝達 / 子宮内環境
Outline of Final Research Achievements

While embryos transfer to recipient females is a useful experimental technique for biology and experimental animal research, it has yet to be determined whether these artificial reproduction technique and the maternal factor affect the phenotype of offspring, especially higher brain function. We showed that high learning ability of Tokai high avoider (THA) rat offspring was not replicate by embryos transfer technique utilizing surrogate female Wistar rats that are low avoidance phenotype. However, a postnatal cross-fostering investigation with the offspring of Wistar rat and THA rat showed that maternal care such as postnatal behavior and lactation trait were not much difference between dams of low avoidance Wistar rat and THA rat. We conclude that the offspring phenotype, although unchanged, has an imperceptible effect on the learning ability of embryos transfer-derived THA rats through the intrauterine environment of the recipient.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Remarks (2 results)

  • [Journal Article] The intrauterine environment affects learning ability of Tokai high avoider rat offspring derived using cryopreservation and embryo transfer-mediated reproduction.2017

    • Author(s)
      Endo H, Eto T, Yoshii F, Owada S, Watanabe T, Tatemichi M, Kimura M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 22;489(2) Issue: 2 Pages: 211-216

    • DOI

      10.1016/j.bbrc.2017.05.133

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acetamiprid Accumulates in Different Amounts in Murine Brain Regions.2016

    • Author(s)
      Terayama H, Endo H, Tsukamoto H, Matsumoto K, Umezu M, Kanazawa T, Ito M, Sato T, Naito M, Kawakami S, Fujino Y, Tatemichi M, Sakabe K.
    • Journal Title

      Int J Environ Res Public Health

      Volume: 13(10) Issue: 10 Pages: 937-937

    • DOI

      10.3390/ijerph13100937

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Remarks] 東海大学医学部基盤診療学系 衛生学公衆衛生学

    • URL

      http://health.med.u-tokai.ac.jp/index.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Remarks] 東海大学医学部衛生学公衆衛生学

    • URL

      http://health.med.u-tokai.ac.jp/research.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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