| Project/Area Number |
15K12737
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MINAMI Atsushi 北海道大学, 大学院理学研究院, 助教 (40507191)
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|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | チトクロームP450 / 酸化酵素 / 天然物 / 生合成 |
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| Outline of Final Research Achievements |
Heterologous expression of cytochrome P450 for fungal natural product biosynthesis has been employed. We succeeded to prepare library of multiple P450-expressed transformants. Using this unique library, we performed the screening the transformants and found various conversion to generate a number of new metabolites although their productions were relatively low.
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