| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We aimed to synthesize and functionalize novel caged compounds, to which the thiochromone-type photolabile protecting group (TCM) is introduced. This TCM can protect various alcohols, amines, and phosphoric acids, and can be converted to a highly fluorescent compound after the uncaging process. We synthesized thymidine, resveratrol, and beta-cyclodextrin caged compounds with our TCM. Photoirradiation, namely uncaging, of these TCM-caged thymidine, resveratrol, and beta-cyclodextrin led to the recovery of their original compounds, respectively. Recovered compounds showed their own biological activity. Totally, we could demonstrate that the TCM protecting group is effective for the creation of various types of caged compounds.
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