Studies on life span regulation by endogenous substances

Research Project

Project/Area Number	15K12752
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Chemical biology
Research Institution	Tohoku University
Principal Investigator	Arimoto Hirokazu 東北大学, 生命科学研究科, 教授 (60262789)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	寿命制御機構 / 寿命延長 / 老化 / 寿命 / 内因性物質
Outline of Final Research Achievements	Recently, several endogenous substances have been reported to suppress aging of animals. In this study, we focused on endogenous compounds derived from nitric oxide, and studied its effects on life span extentions using nematode C. elegans. The lifespan extension effect depended on daf-16, skn-1 genes but not on daf-2 and eat-2 genes. The prolonged lifespan by the NO-derived compound was suppressed by knockdown of an autophagy-related gene atg5.