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Depicting neural circuit that evokes cataplexy

Research Project

Project/Area Number 15K12768
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Research InstitutionUniversity of Tsukuba (2016)
Kanazawa University (2015)

Principal Investigator

SAKURAI Takeshi  筑波大学, 医学医療系, 教授 (60251055)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsナルコレプシー / オレキシン / 視床下部 / 睡眠障害 / カタプレキシー / 情動
Outline of Final Research Achievements

We identified several brain regions that are implicated in the emergence of cataplexy-like episodes in orexin/ataxin-3 mice, a rodent model of narcolepsy. Optogenetic excitation with specific stimulating conditions evoke cataplexy in these mice.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (27 results)

All 2017 2016 2015

All Journal Article (12 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 12 results,  Open Access: 9 results,  Acknowledgement Compliant: 3 results) Presentation (14 results) (of which Int'l Joint Research: 5 results,  Invited: 6 results) Book (1 results)

  • [Journal Article] Serotonin neurons of the dorsal raphe mediate the anti-cataplectic action of orexin neurons by reducing the amygdala activity2017

    • Author(s)
      Hasegawa, E., Maejima, T., Yoshida, T., Masseck O.A., Herlitze, S., Yoshioka, M., Sakurai, T., Mieda, M.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 114 Issue: 17

    • DOI

      10.1073/pnas.1614552114

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Odour-induced analgesia mediated by hypothalamic orexin neurons in mice.2016

    • Author(s)
      Tashiro S, Yamaguchi R, Ishikawa S, Sakurai T, Kajiya K, Kanmura Y, Kuwaki T, Kashiwadani H.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 37129-37129

    • DOI

      10.1038/srep37129

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] QRFP-deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-like behavior2016

    • Author(s)
      Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 11 Pages: e0164716-e0164716

    • DOI

      10.1371/journal.pone.0164716

    • NAID

      120007129233

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period.2016

    • Author(s)
      Mieda M, Okamoto H, Sakurai T.
    • Journal Title

      Curr Biol.

      Volume: S0960-9822(16) Issue: 18 Pages: 30773-4

    • DOI

      10.1016/j.cub.2016.07.022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mesolimbic neuropeptide W coordinates stress responses under novel environments.2016

    • Author(s)
      Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113(21) Issue: 21 Pages: 6023-8

    • DOI

      10.1073/pnas.1518658113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sleep Control, GPCRs, and Glucose Metabolism.2016

    • Author(s)
      Tsuneki H, Sasaoka T, Sakurai T.
    • Journal Title

      Trends Endocrinol Metab.

      Volume: 27(9) Issue: 9 Pages: 633-42

    • DOI

      10.1016/j.tem.2016.06.011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice.2016

    • Author(s)
      Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.
    • Journal Title

      Endocrinology

      Volume: 157 Issue: 1 Pages: 195-206

    • DOI

      10.1210/en.2015-1488

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Comprehensive Behavioral Analysis of Male Ox1r (-/-) Mice Showed Implication of OrexinReceptor-1 in Mood, Anxiety, and Social Behavior.2015

    • Author(s)
      Abbas MG, Shoji H, Soya S, Hondo M, Miyakawa T, Sakurai T.
    • Journal Title

      Front Behav Neurosci.

      Volume: 9 Pages: 324-324

    • DOI

      10.3389/fnbeh.2015.00324

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hypocretin/orexin prevents recovery from sickness.2015

    • Author(s)
      Tanaka S, Toyoda H, Honda Y, Seki Y, Sakurai T, Honda K, Kodama T.
    • Journal Title

      Biomed Rep.

      Volume: 3 Pages: 648-650

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease.2015

    • Author(s)
      Kitajima S, Iwata Y, Furuichi K, Sagara A, Shinozaki Y, Toyama T, Sakai N, Shimizu M, Sakurai T, Kaneko S, Wada T.
    • Journal Title

      Clin Exp Nephrol

      Volume: 20 Issue: 2 Pages: 218-25

    • DOI

      10.1007/s10157-015-1150-y

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.2015

    • Author(s)
      Nishizawa D et al.
    • Journal Title

      Mol Brain.

      Volume: 8 Issue: 1 Pages: 50-50

    • DOI

      10.1186/s13041-015-0142-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cellular Clocks in AVP Neurons of the SCN Are Critical for Interneuronal Coupling Regulating Circadian Behavior Rhythm.2015

    • Author(s)
      Mieda M, Ono D, Hasegawa E, Okamoto H, Honma K, Honma S, Sakurai T.
    • Journal Title

      Neuron

      Volume: 85 Issue: 5 Pages: 1103-1116

    • DOI

      10.1016/j.neuron.2015.02.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] セロトニンによるオレキシンニューロンの制御が睡眠・覚醒状態に与える影響2016

    • Author(s)
      齊藤夕貴、前島隆司、辻野なつ子、阿部学、崎村建司、櫻井 武
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル 東京都新宿区
    • Year and Date
      2016-07-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] オレキシンは扁桃体へのノルアドレナリン入力を制御し恐怖行動の発現に関与する2016

    • Author(s)
      征矢晋吾、前島隆司、桜井 武
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス脳におけるヒスタミン作動性神経細胞に直接シナプス入力を送る神経細胞のマッピング2016

    • Author(s)
      前島隆司、西谷光広、齋藤夕貴、櫻井 武
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] オレキシン産生ニューロンの抗カタプレキシー作用は背側縫線核・セロトニン作動性ニューロンの扁桃体抑制により仲介される2016

    • Author(s)
      長谷川恵美、前島隆司、櫻井 武、三枝理博
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 視床下部外側野のオレキシンニューロンへ直接入力する神経の同定2016

    • Author(s)
      齊藤夕貴、前島隆司、櫻井 武
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Orexins and Orexin Receptors in the Regulation of Sleep and Wakefulness.2016

    • Author(s)
      Sakurai, T
    • Organizer
      The Sixteenth Conference of Peace through Mind/Brain Science
    • Place of Presentation
      Hamamatsu, Japan
    • Year and Date
      2016-02-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural Circuits of Orexin Neurons: Interface of Systems of Emotion, Energy Homeostasis and Arousal.2016

    • Author(s)
      Takeshi Sakurai
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology Satellite Symposium
    • Place of Presentation
      COEX Convention Center, Korea ソウル市韓国
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural circuit of orexin neurons, and its role in regulating the sleep/wakefulness states2015

    • Author(s)
      Sakurai, T
    • Organizer
      IBRO-Kemali School 2015
    • Place of Presentation
      Institute of Biomolecular Chemistry of CNR, Pozzuoli, Italy
    • Year and Date
      2015-09-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of adult born neurons during sleep.2015

    • Author(s)
      Sakaguchi, M., Kumar, D., Hayashi, M., Yu, L.M., McHugh, T.J., Sakurai, T
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society.
    • Place of Presentation
      神戸コンベンションセンター、神戸、兵庫県
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior thythm.2015

    • Author(s)
      Mieda, M., Ono, D., Hasegawa, E., Okamoto, H., Honma, K., Honma, S., Sakurai, T.
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society.
    • Place of Presentation
      神戸コンベンションセンター、神戸、兵庫県
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.2015

    • Author(s)
      Hasegawa, E., Yanagisawa, M., Sakurai, T., Mieda, M.
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society.
    • Place of Presentation
      神戸コンベンションセンター、神戸、兵庫県
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Neuronal mechanisms by which orexin neurons are activated in response to emotionally-salient cues and contexts2015

    • Author(s)
      Sakurai, T
    • Organizer
      Think-Tank-Meeting 2015:Current and Future Directions in Narcolepsy Research
    • Place of Presentation
      Bigorio, Switzerland
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Orexins and orexin receptors in the regulation of sleep and wakefulness.2015

    • Author(s)
      Sakurai, T
    • Organizer
      3rd Alpine Sleep Summer School 2015
    • Place of Presentation
      Lugano, Switzerland
    • Year and Date
      2015-06-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 視交叉上核バソプレシン産生ニューロンの細胞時計はニューロン間カップリングの調節を通して概日行動リズムを制御する2015

    • Author(s)
      8.三枝理博、小野大輔、長谷川恵美、岡本仁、本間研一、本間さと、櫻井 武
    • Organizer
      第12回GPCR研究会
    • Place of Presentation
      未来館ホール お台場
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 睡眠障害のなぞを解く 「眠りのしくみ」から「眠るスキル」まで2015

    • Author(s)
      櫻井 武
    • Total Pages
      144
    • Publisher
      講談社
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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