New scheme of the basal ganglia in Parkinson's disease
| Project/Area Number |
15K12770
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
苅部 冬紀 同志社大学, 研究開発推進機構, 准教授 (60312279)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 大脳基底核 / 線条体 / 基底核 / 淡蒼球外節 |
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| Outline of Final Research Achievements |
In rodents, the dorsolateral striatum regulates voluntary movement by integrating excitatory inputs from the motor-related cerebral cortex and thalamus to produce contingent inhibitory output to other basal ganglia nuclei. Striatal parvalbumin (PV)-producing interneurons receiving this excitatory input then inhibit medium spiny neurons (MSNs) and modify their outputs. Our observations of thalamostriatal and corticostriatal appositions by immunohistochemistry for pathway-specific vesicular glutamate transporters confirmed that thalamic inputs preferentially, and cortical ones less preferentially, made apposition on proximal dendrites of PV neurons. This axodendritic organization suggests that PV neurons produce fast and reliable inhibition of MSNs in response to thalamic inputs and process excitatory inputs from motor cortices locally and plastically, possibly together with other GABAergic and dopaminergic dendritic inputs, to modulate MSN inhibition.
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Report
(4 results)
Research Products
(50 results)
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[Presentation] 大脳基底核回路2017
Author(s)
Fumino Fujiyama
Organizer
第40回日本神経科学大会
Place of Presentation
幕張メッセ（千葉・幕張）
Year and Date
2017-07-20
Related Report
Invited
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[Presentation] 大脳基底核回路の形態学的解析2016
Author(s)
Fumino Fujiyama
Organizer
第59回日本脳循環代謝学会学術集会
Place of Presentation
あわぎんホール（徳島）
Year and Date
2016-11-11
Related Report
Invited
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[Presentation] 大脳基底核の真の姿を探して2015
Author(s)
藤山文乃
Organizer
第3回さいたまパーキンソン病カンファレンス
Place of Presentation
ラフレさいたま（さいたま市）
Year and Date
2015-04-07
Related Report
Invited
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