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Neural circuit of frustration aggression

Research Project

Project/Area Number 15K12773
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Research InstitutionUniversity of Tsukuba

Principal Investigator

Takahashi Aki  筑波大学, 人間系, 准教授 (30581764)

Co-Investigator(Kenkyū-buntansha) 小出 剛  国立遺伝学研究所, 遺伝形質研究系, 准教授 (20221955)
小川 園子  筑波大学, 人間系, 教授 (50396610)
Research Collaborator Russo Scott J  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords苛立ち / 攻撃行動 / マウス / 背側縫線核
Outline of Final Research Achievements

In this study, we studied neural circuit that is involved in an escalation of aggressive behavior induced by social instigation. Social instigation is a procedure that animals can see, smell, and hear the existence of other male but he cannot directly attack the opponent due to the partition. This procedure induces psychological excitation and causes an escalation of aggressive behavior of the male mouse in the following social encounter. We found that the dorsal raphe nucleus, which contains largest number of serotonin neurons in the brain, are involved in this escalation of aggressive behavior. Especially, excitatory glutamate input in the dorsal raphe nucleus determines the level of aggressive behavior in the male mice.

Academic Significance and Societal Importance of the Research Achievements

人間社会において暴力は大きな問題となっているが、この暴力行為の引き金となる主な原因に、欲求不満などによる「苛立ち」がある。ヒトにおける数少ない苛立ちの脳研究からは、動物研究で攻撃行動に関わることが示されている脳部位の一部が、苛立ちによっても活性化されることが報告されているが、その空間解像度は高いとは言えない。本研究はマウスを用いて、このような苛立ちに関わる神経回路を詳細に解明することを目指したものであり、その結果、セロトニン神経系を含む神経回路の関与が明らかになってきた。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (56 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (18 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 17 results,  Open Access: 8 results,  Acknowledgement Compliant: 6 results) Presentation (31 results) (of which Int'l Joint Research: 20 results,  Invited: 2 results) Remarks (4 results)

  • [Int'l Joint Research] Icahn School of Medicine at Mount Sinai(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] The Rockefeller University/Icahn School of Medicine at Mount Sinai(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] The Rockefeller University/Icahn Schoold of Medicine at Mount Sinai(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Cell-Type-Specific Role of FosB in Nucleus Accumbens In Modulating Intermale Aggression.2018

    • Author(s)
      Aleyasin H, Flanigan ME, Golden SA, Takahashi A, Menard C, Pfau ML, Multer J, Pina J, McCabe KA, Bhatti N, Hodes GE, Heshmati M, Neve RL, Nestler EJ, Heller EA, Russo SJ
    • Journal Title

      The Journal of Neuroscience

      Volume: 38 Issue: 26 Pages: 5913-5924

    • DOI

      10.1523/jneurosci.0296-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combinatorial Psycho-Pharmacological Approaches for the Treatment of Abnormal Aggression2018

    • Author(s)
      Golden SA, Takahashi A.
    • Journal Title

      Neuropsychopharmacology

      Volume: 43 Issue: 2 Pages: 233-234

    • DOI

      10.1038/npp.2017.174

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cell-type specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.2018

    • Author(s)
      Heshmati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan ME, Pfau ML, Goff PH, Hodes GE, Lepack A, Bicks L, Takahashi A, Chandra R, Turecki G, Lobo MK, Maze I, Golden SA, Russo SJ
    • Journal Title

      Proceedings of the National Academy of Sciences U S A

      Volume: 115 Issue: 5 Pages: 1111-1116

    • DOI

      10.1073/pnas.1719014115

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Aggression, social stress and the immune system in humans and animal models.2018

    • Author(s)
      Takahashi A, Flanigan ME, McEwen BS, Russo SJ
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 12 Pages: 56-56

    • DOI

      10.3389/fnbeh.2018.00056

    • NAID

      120007134291

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice2017

    • Author(s)
      Okabe, S., Tsuneoka, Y., Takahashi, A., Ooyama, R., Watarai, A., Maeda, S., Honda, Y., Nagasawa, M., Mogi, K., Nishimori, K., Kuroda, M., Koide, T., Kikusui, T.
    • Journal Title

      Psychoneuroendocrinology

      Volume: 79 Pages: 20-30

    • DOI

      10.1016/j.psyneuen.2017.01.036

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 過剰な攻撃行動の神経生物学―動物行動神経科学の視点から2017

    • Author(s)
      高橋阿貴
    • Journal Title

      臨床精神医学

      Volume: 49 Pages: 1077-1082

    • Related Report
      2017 Research-status Report
  • [Journal Article] Automated Estimation of Mouse Social Behaviors Based on a Hidden Markov Model.2017

    • Author(s)
      Arakawa T, Tanave A, Takahashi A, Kakihara S, Koide T, Tsuchiya T.
    • Journal Title

      Methods in Molecular Biology

      Volume: 1552 Pages: 185-197

    • DOI

      10.1007/978-1-4939-6753-7_14

    • ISBN
      9781493967513, 9781493967537
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An emerging role for the lateral habenula in aggressive behavior.2017

    • Author(s)
      Flanigan M, Aleyasin H, Takahashi A, Golden SA, Russo SJ.
    • Journal Title

      Pharmacology Biochemistry and Behavior

      Volume: 162 Pages: 79-86

    • DOI

      10.1016/j.pbb.2017.05.003

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice.2017

    • Author(s)
      Horii Y, Nagasawa T, Sakakibara H, Takahashi A, Tanave A, Matsumoto Y, Nagayama H, Yoshimi K, Yasuda MT, Shimoi K, Koide T.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 6991-6991

    • DOI

      10.1038/s41598-017-07233-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishment of a repeated social defeat stress model in female mice.2017

    • Author(s)
      Takahashi A, Chung J, Zhang S, Zhang H, Grossman Y, Aleyasin H, Flanigan ME, Pfau ML, Menard C, Dumitriu D, Hodes GE, McEwen BS, Nestler EJ, Han MH, Russo SJ
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12838-12838

    • DOI

      10.1038/s41598-017-12811-8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Social stress induces neurovascular pathology promoting depression.2017

    • Author(s)
      Menard C, Pfau ML, Hodes GE, Kana V, Wang VX, Bouchard S, Takahashi A, Flanigan ME, Aleyasin H, LeClair KB, Janssen WG, Labonte B, Parise EM, Lorsch ZS, Golden SA, Heshmati M, Tamminga C, Turecki G, Campbell M, Fayad ZA, Tang CY, Merad M, Russo SJ.
    • Journal Title

      Nature Neuroscience

      Volume: 20 Issue: 12 Pages: 1752-1760

    • DOI

      10.1038/s41593-017-0010-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice.2016

    • Author(s)
      Golden SA, Aleyasin H, Heins R, Flanigan M, Heshmati M, Takahashi A, Russo SJ and Shaham Y
    • Journal Title

      Genes, Brain, and Behavior

      Volume: 16 Issue: 1 Pages: 44-55

    • DOI

      10.1111/gbb.12310

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.2016

    • Author(s)
      Hirata H, Takahashi A, Shimoda Y, Koide T.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 1 Pages: e0147887-e0147887

    • DOI

      10.1371/journal.pone.0147887

    • NAID

      120007129617

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice.2015

    • Author(s)
      Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B, Miczek KA, Koide T
    • Journal Title

      Journal of Neuroscience.

      Volume: 35(16) Issue: 16 Pages: 6452-6463

    • DOI

      10.1523/jneurosci.2450-14.2015

    • NAID

      120007130264

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Escalated Aggression in Animal Models: Shedding New Light on Mesocorticolimbic Circuits.2015

    • Author(s)
      Miczek KA, Takahashi A, Gobrogge KL, Hwa LS, de Almeida RMM
    • Journal Title

      Current Opinion in Behavioral Sciences

      Volume: 3 Pages: 90-95

    • DOI

      10.1016/j.cobeha.2015.02.007

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] α2-containing GABA(A) receptors: a requirement for midazolam-escalated aggression and social approach in mice.2015

    • Author(s)
      Newman EL, Smith KS, Takahashi A, Chu A, Hwa LS, Chen Y, DeBold JF, Rudolph U, Miczek KA.
    • Journal Title

      Psychopharmacology

      Volume: 232 Issue: 23 Pages: 4359-4369

    • DOI

      10.1007/s00213-015-4069-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mapping of genetic factors that elicit intermale aggressive behavior on Mouse Chromosome 15: intruder effects and the complex genetic basis2015

    • Author(s)
      Takahashi, A., Sugimoto, H., Kato, S., Shiroishi, T. and Koide, T.
    • Journal Title

      PLOS ONE

      Volume: 10(9): e0137764 Issue: 9 Pages: 1-20

    • DOI

      10.1371/journal.pone.0137764

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress.2015

    • Author(s)
      Hodes GE, Pfau ML, Purushothaman I, Ahn HF, Golden SA, Christoffel DJ, Magida J, Brancato A, Takahashi A, Flanigan ME, Ménard C, Aleyasin H, Koo JW, Lorsch ZS, Feng J, Heshmati M, Wang M, Turecki G, Neve R, Zhang B, Shen L, Nestler EJ, Russo SJ.
    • Journal Title

      Journal of Neuroscience

      Volume: 35 Issue: 50 Pages: 16362-16376

    • DOI

      10.1523/jneurosci.1392-15.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Phasic increase of interleukin 1 in the dorsal raphe nucleus affects inter-male aggressive behavior2019

    • Author(s)
      Takahashi A, Aleyasin H, Stavarache MA, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Ogawa S, McEwen BS and Russo SJ
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies (FAOPS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスモデルから探る過剰な攻撃性に関わる神経メカニズム2018

    • Author(s)
      高橋阿貴
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Prefrontal and subcortical neural mechanisms regulating escalated aggression in mice2018

    • Author(s)
      Takahashi A
    • Organizer
      30th APS Annual Convention
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Individual difference of aggressive behavior and interleukin 1 beta in the dorsal raphe nucleus2018

    • Author(s)
      Takahashi A, Aleyasin H, Stavarache MA, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Ogawa S, McEwen BS and Russo SJ
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Orexin inputs to GABAergic lateral habenula neurons control aggression valence2018

    • Author(s)
      Flanigan M, Aleyasin H, Leclair L, Lucas EK, Matikainen-Ankney BA, Takahashi A, Menard C, Bouchard S, Pfau ML, Golden SA, Calipari ES, Nestler EJ, Dileone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modulation of dorsal raphe neuron activity by interleukin 1 beta and inter-male aggression in male mice2018

    • Author(s)
      Takahashi A, Aleyasin H, Stavarache MA, Ogawa S, Russo SJ
    • Organizer
      第78回日本動物心理学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 視床下部内側視索前野に局在するエストロゲン受容体発現細胞集団は、 発現するエストロゲン受容体のサブタイプによって異なる遠心性投射パターンを示すのか?2018

    • Author(s)
      村川友哲, 佐越祥子, 高橋阿貴, 小川園子
    • Organizer
      第29回日本行動神経内分泌研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The role of interleukin 1β in the brain on individual difference of inter-male aggression in the mouse.2018

    • Author(s)
      Takahashi A, Aleyasin H, Stavarache MA, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Ogawa S, McEwen BS, Russo SJ
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report
  • [Presentation] Developmental changes and sex differences of ultrasonic vocalization in mice during social interactions2018

    • Author(s)
      Sano K, Saito K, Takahashi A, Ogawa S
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of optogenetic manipulation of dorsal raphe serotonergic neuronal activity on pup-caring behavior in virgin female mice.2017

    • Author(s)
      Takenawa S, Nakamura S, Takahashi A, Tamanaka A, Ogawa S
    • Organizer
      The 94th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Act City Hamamatsu、浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Projections from the dorsal raphe nucleus that is involved in escalation of aggression2017

    • Author(s)
      Takahashi A
    • Organizer
      The 40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 雄間攻撃行動に関わる背側縫線核の役割2017

    • Author(s)
      高橋阿貴
    • Organizer
      第28回JSBN
    • Related Report
      2017 Research-status Report
  • [Presentation] Neuromodulatory effect of cytokine in the dorsal raphe nucleus and individual difference of aggression.2017

    • Author(s)
      Takahashi A, Aleyasin H, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, McEwen BS and Russo SJ
    • Organizer
      The International Behavioral Neuroscience Society (IBNS) 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウスの雄間攻撃行動の個体差おける免疫系の関与2017

    • Author(s)
      Takahashi A, Aleyasin H, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, McEwen BS and Russo SJ
    • Organizer
      行動2017(日本動物心理学会、日本動物行動学会、応用動物行動学会、日本家畜管理学会、日本行動神経内分泌学研究会の合同大会)
    • Related Report
      2017 Research-status Report
  • [Presentation] 視床下部腹内側核エストロゲン受容体 α 陽性神経細胞への特異的な操作が雌マウスの自発的活動量に及ぼす効果2017

    • Author(s)
      佐越祥子・武縄聡・高橋阿貴・小川園子
    • Organizer
      行動2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Effects of optogenetic manipulation on dorsal raphe serotonergic neuronal activity increases pup-caring behavior in virgin female mice.2017

    • Author(s)
      Takenawa S, Nakamura S, Takahashi A, Tanaka K, Yamanaka A, Ogawa S
    • Organizer
      行動2017
    • Related Report
      2017 Research-status Report
  • [Presentation] 社会的探索行動場面での雄マウスの内側扁桃体エストロゲン受容体アルファ陽性細胞の神経活動の解析2017

    • Author(s)
      宮坂藍・武縄聡・西野明日香・高橋阿貴・小川園子
    • Organizer
      行動2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Transcription factor delta-FosB regulates aggressive behavior in male mice in a cell-specific manner2017

    • Author(s)
      Aleyasin H, Flanigan M, Golden SA, Takahashi A, Pina J, Menard C, Pfau ML, Hodes G, Heshmati M, Heller E, Russo SJ
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A novel lateral habenula microcircuit mediating appetitive aggression2017

    • Author(s)
      Flanigan M, Aleyasin H, Matikainen-Ankney BA, Takahashi A, Calipari ES, Golden SA, Menard C, Pfau ML, Hodes GE, Russo S
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modulation of neuroligin-2 in the nucleus accumbens alters stress and dominance behaviors.2017

    • Author(s)
      Heshimati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan M, Pfau ML, Goff PH, Hodes GE, Takahashi A, Lepack A, Bicks L, Chandra R, Lobo M, Maze I, Golden SA, Russo SJ
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Establishment of a repeated social defeat stress model in female mice2017

    • Author(s)
      Chung JR, Takahashi A, Zhang S, Zhang H, Grossman Y, Aleyasin H, Flanigan M, Pfau M, Menard C, Dumitriu D, Hodes G, McEwen B, Nestler E, Han MH, Russo SJ
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Social stress induces neurovascular pathology promoting depression.2017

    • Author(s)
      Menard C, Pfau ML, Hodes GE, KANA V, Wang VX, Bouchard S, Takahashi A, Flanigan M, Aleyasin H, Leclair K, Janssen WG, Labonte B, Parise EM, Lorsch ZS, Golden SA, Heshmati M, Tamminga CA, Turecki G, Campbell M, Fayad Z, Tang CY, Menard M, Russo SJ
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The role of central interleukin 1 in aggressive behavior2016

    • Author(s)
      Takahashi A, Aleyasin H, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, McEwen BS and Russo SJ
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego Convention Center、米国・サンディエゴ
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Establishment of repeated social defeat stress model in female mice.2016

    • Author(s)
      Russo RJ, Takahashi A, Zhang H, Zhang S, Grossman Y, Aleyasin H, Flanigan ME, Pena C, Pfau ML, Menard C, Hodes GE, Nestler EJ, Han MH
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego Convention Center、米国・サンディエゴ
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cell specific role of delta-FosB in aggressive behavior in male mice.2016

    • Author(s)
      Aleyasin H, Golden SA, Takahashi A, Flanigan ME, Pfau ML, Menard C, Hodes GE, Heshmati M, Multer J, Bicks L, Tai J, Heller E, Russo SJ
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego Convention Center、米国・サンディエゴ
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Lateral habenula orexin receptor-2 signaling controls aggression reward.2016

    • Author(s)
      Flanigan M, Aleyasin H, Takahashi A, Calipari ES, Menard M, Pfau ML, Russo SJ
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego Convention Center、米国・サンディエゴ
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A cell-type specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.2016

    • Author(s)
      Heshmati M, Aleyasin H, Menard C, Flanigan ME, Pfau ML, Goff PH, Hodes GE, Takahashi A, Lepack A, Bicks L, Christoffel DJ, Chandra R, Friedman AK, Turecki G, Han MH, Lobo M, Maze I, Golden SA, Russo SJ
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego Convention Center、米国・サンディエゴ
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of blood-brain barrier permeability and tight junction protein claudin 5 in vulnerability to social stress and major depressive disorder.2016

    • Author(s)
      Menard C, Pfau ML, Wang VX, Kana V, Hodes GE, Aleyasin H, Flanigan ME, Takahashi A, Golden SA, Hesmati M, Campell M, Merad M, Tang CY, Russo SJ
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego Convention Center、米国・サンディエゴ
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neurobehavioral mechanisms of escalated aggression: the role of the dorsal raphe nucleus and prefrontal cortex in male mice.2016

    • Author(s)
      Takahashi A
    • Organizer
      International Society for Research on Aggression 22nd World Meeting
    • Place of Presentation
      University of New South Wales、オーストラリア・シドニー
    • Year and Date
      2016-07-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neurobiology of escalated aggression2016

    • Author(s)
      Takahashi A.
    • Organizer
      AAAS 2016
    • Place of Presentation
      Marriott Wardman Park、米国・ワシントンDC
    • Year and Date
      2016-02-13
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mapping of genetic factors for intermale aggressive behavior on mouse chromosome 15.2015

    • Author(s)
      Takahashi A, Sugimoto H, Kato T, Shiroishi T, Koide T.
    • Organizer
      Neuroscience 2015.
    • Place of Presentation
      McCormick Place、米国・シカゴ
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] TSUKUBA FUTURE #097:マウスの行動に魅せられて

    • URL

      http://www.tsukuba.ac.jp/notes/097/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 雌マウスの社会的敗北ストレスモデルの確立

    • URL

      https://www.tsukuba.ac.jp/attention-research/r201710161400.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 雌マウスの社会的敗北ストレスモデルの確立ー女性のストレス関連疾患を生物学的に研究するために

    • URL

      https://academist-cf.com/journal/?p=6398

    • Related Report
      2017 Research-status Report
  • [Remarks] 筑波大学研究者総覧_高橋阿貴

    • URL

      http://www.trios.tsukuba.ac.jp/researcher/0000003646

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-02-16  

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