Neural circuit of frustration aggression
Project/Area Number |
15K12773
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Basic / Social brain science
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
小出 剛 国立遺伝学研究所, 遺伝形質研究系, 准教授 (20221955)
小川 園子 筑波大学, 人間系, 教授 (50396610)
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Research Collaborator |
Russo Scott J
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | 苛立ち / 攻撃行動 / マウス / 背側縫線核 |
Outline of Final Research Achievements |
In this study, we studied neural circuit that is involved in an escalation of aggressive behavior induced by social instigation. Social instigation is a procedure that animals can see, smell, and hear the existence of other male but he cannot directly attack the opponent due to the partition. This procedure induces psychological excitation and causes an escalation of aggressive behavior of the male mouse in the following social encounter. We found that the dorsal raphe nucleus, which contains largest number of serotonin neurons in the brain, are involved in this escalation of aggressive behavior. Especially, excitatory glutamate input in the dorsal raphe nucleus determines the level of aggressive behavior in the male mice.
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Academic Significance and Societal Importance of the Research Achievements |
人間社会において暴力は大きな問題となっているが、この暴力行為の引き金となる主な原因に、欲求不満などによる「苛立ち」がある。ヒトにおける数少ない苛立ちの脳研究からは、動物研究で攻撃行動に関わることが示されている脳部位の一部が、苛立ちによっても活性化されることが報告されているが、その空間解像度は高いとは言えない。本研究はマウスを用いて、このような苛立ちに関わる神経回路を詳細に解明することを目指したものであり、その結果、セロトニン神経系を含む神経回路の関与が明らかになってきた。
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Report
(5 results)
Research Products
(56 results)
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[Journal Article] Cell-Type-Specific Role of FosB in Nucleus Accumbens In Modulating Intermale Aggression.2018
Author(s)
Aleyasin H, Flanigan ME, Golden SA, Takahashi A, Menard C, Pfau ML, Multer J, Pina J, McCabe KA, Bhatti N, Hodes GE, Heshmati M, Neve RL, Nestler EJ, Heller EA, Russo SJ
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Journal Title
The Journal of Neuroscience
Volume: 38
Issue: 26
Pages: 5913-5924
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Cell-type specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.2018
Author(s)
Heshmati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan ME, Pfau ML, Goff PH, Hodes GE, Lepack A, Bicks L, Takahashi A, Chandra R, Turecki G, Lobo MK, Maze I, Golden SA, Russo SJ
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Journal Title
Proceedings of the National Academy of Sciences U S A
Volume: 115
Issue: 5
Pages: 1111-1116
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice2017
Author(s)
Okabe, S., Tsuneoka, Y., Takahashi, A., Ooyama, R., Watarai, A., Maeda, S., Honda, Y., Nagasawa, M., Mogi, K., Nishimori, K., Kuroda, M., Koide, T., Kikusui, T.
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Journal Title
Psychoneuroendocrinology
Volume: 79
Pages: 20-30
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice.2017
Author(s)
Horii Y, Nagasawa T, Sakakibara H, Takahashi A, Tanave A, Matsumoto Y, Nagayama H, Yoshimi K, Yasuda MT, Shimoi K, Koide T.
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 6991-6991
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Establishment of a repeated social defeat stress model in female mice.2017
Author(s)
Takahashi A, Chung J, Zhang S, Zhang H, Grossman Y, Aleyasin H, Flanigan ME, Pfau ML, Menard C, Dumitriu D, Hodes GE, McEwen BS, Nestler EJ, Han MH, Russo SJ
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 12838-12838
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Social stress induces neurovascular pathology promoting depression.2017
Author(s)
Menard C, Pfau ML, Hodes GE, Kana V, Wang VX, Bouchard S, Takahashi A, Flanigan ME, Aleyasin H, LeClair KB, Janssen WG, Labonte B, Parise EM, Lorsch ZS, Golden SA, Heshmati M, Tamminga C, Turecki G, Campbell M, Fayad ZA, Tang CY, Merad M, Russo SJ.
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Journal Title
Nature Neuroscience
Volume: 20
Issue: 12
Pages: 1752-1760
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress.2015
Author(s)
Hodes GE, Pfau ML, Purushothaman I, Ahn HF, Golden SA, Christoffel DJ, Magida J, Brancato A, Takahashi A, Flanigan ME, Ménard C, Aleyasin H, Koo JW, Lorsch ZS, Feng J, Heshmati M, Wang M, Turecki G, Neve R, Zhang B, Shen L, Nestler EJ, Russo SJ.
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Journal Title
Journal of Neuroscience
Volume: 35
Issue: 50
Pages: 16362-16376
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Phasic increase of interleukin 1 in the dorsal raphe nucleus affects inter-male aggressive behavior2019
Author(s)
Takahashi A, Aleyasin H, Stavarache MA, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Ogawa S, McEwen BS and Russo SJ
Organizer
9th Federation of the Asian and Oceanian Physiological Societies (FAOPS)
Related Report
Int'l Joint Research
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[Presentation] Individual difference of aggressive behavior and interleukin 1 beta in the dorsal raphe nucleus2018
Author(s)
Takahashi A, Aleyasin H, Stavarache MA, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Ogawa S, McEwen BS and Russo SJ
Organizer
Neuroscience 2018
Related Report
Int'l Joint Research
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[Presentation] Orexin inputs to GABAergic lateral habenula neurons control aggression valence2018
Author(s)
Flanigan M, Aleyasin H, Leclair L, Lucas EK, Matikainen-Ankney BA, Takahashi A, Menard C, Bouchard S, Pfau ML, Golden SA, Calipari ES, Nestler EJ, Dileone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ
Organizer
Neuroscience 2018
Related Report
Int'l Joint Research
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[Presentation] The role of interleukin 1β in the brain on individual difference of inter-male aggression in the mouse.2018
Author(s)
Takahashi A, Aleyasin H, Stavarache MA, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Ogawa S, McEwen BS, Russo SJ
Organizer
The 41st Annual Meeting of the Japan Neuroscience Society
Related Report
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[Presentation] マウスの雄間攻撃行動の個体差おける免疫系の関与2017
Author(s)
Takahashi A, Aleyasin H, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, McEwen BS and Russo SJ
Organizer
行動2017(日本動物心理学会、日本動物行動学会、応用動物行動学会、日本家畜管理学会、日本行動神経内分泌学研究会の合同大会)
Related Report
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[Presentation] Transcription factor delta-FosB regulates aggressive behavior in male mice in a cell-specific manner2017
Author(s)
Aleyasin H, Flanigan M, Golden SA, Takahashi A, Pina J, Menard C, Pfau ML, Hodes G, Heshmati M, Heller E, Russo SJ
Organizer
Neuroscience 2017
Related Report
Int'l Joint Research
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[Presentation] Modulation of neuroligin-2 in the nucleus accumbens alters stress and dominance behaviors.2017
Author(s)
Heshimati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan M, Pfau ML, Goff PH, Hodes GE, Takahashi A, Lepack A, Bicks L, Chandra R, Lobo M, Maze I, Golden SA, Russo SJ
Organizer
Neuroscience 2017
Related Report
Int'l Joint Research
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[Presentation] Establishment of a repeated social defeat stress model in female mice2017
Author(s)
Chung JR, Takahashi A, Zhang S, Zhang H, Grossman Y, Aleyasin H, Flanigan M, Pfau M, Menard C, Dumitriu D, Hodes G, McEwen B, Nestler E, Han MH, Russo SJ
Organizer
Neuroscience 2017
Related Report
Int'l Joint Research
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[Presentation] Social stress induces neurovascular pathology promoting depression.2017
Author(s)
Menard C, Pfau ML, Hodes GE, KANA V, Wang VX, Bouchard S, Takahashi A, Flanigan M, Aleyasin H, Leclair K, Janssen WG, Labonte B, Parise EM, Lorsch ZS, Golden SA, Heshmati M, Tamminga CA, Turecki G, Campbell M, Fayad Z, Tang CY, Menard M, Russo SJ
Organizer
Neuroscience 2017
Related Report
Int'l Joint Research
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[Presentation] Establishment of repeated social defeat stress model in female mice.2016
Author(s)
Russo RJ, Takahashi A, Zhang H, Zhang S, Grossman Y, Aleyasin H, Flanigan ME, Pena C, Pfau ML, Menard C, Hodes GE, Nestler EJ, Han MH
Organizer
Neuroscience 2016
Place of Presentation
San Diego Convention Center、米国・サンディエゴ
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Cell specific role of delta-FosB in aggressive behavior in male mice.2016
Author(s)
Aleyasin H, Golden SA, Takahashi A, Flanigan ME, Pfau ML, Menard C, Hodes GE, Heshmati M, Multer J, Bicks L, Tai J, Heller E, Russo SJ
Organizer
Neuroscience 2016
Place of Presentation
San Diego Convention Center、米国・サンディエゴ
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] A cell-type specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.2016
Author(s)
Heshmati M, Aleyasin H, Menard C, Flanigan ME, Pfau ML, Goff PH, Hodes GE, Takahashi A, Lepack A, Bicks L, Christoffel DJ, Chandra R, Friedman AK, Turecki G, Han MH, Lobo M, Maze I, Golden SA, Russo SJ
Organizer
Neuroscience 2016
Place of Presentation
San Diego Convention Center、米国・サンディエゴ
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Role of blood-brain barrier permeability and tight junction protein claudin 5 in vulnerability to social stress and major depressive disorder.2016
Author(s)
Menard C, Pfau ML, Wang VX, Kana V, Hodes GE, Aleyasin H, Flanigan ME, Takahashi A, Golden SA, Hesmati M, Campell M, Merad M, Tang CY, Russo SJ
Organizer
Neuroscience 2016
Place of Presentation
San Diego Convention Center、米国・サンディエゴ
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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