Contribution of cortico-basal ganglia loops to the control of upright posture and locomotor movements
| Project/Area Number |
15K12778
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Brain biometrics
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| Research Institution | Iwate Medical University (2017)
Kindai University (2015-2016) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 歩行運動 / 姿勢 / トレッドミル / 神経細胞活動 / ニホンザル / 一次運動野 / 補足運動野 / 背側運動前野 / 歩行 / サル / 単一神経細胞活動 |
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| Outline of Final Research Achievements |
To further understand cortical mechanisms underlying upright posture and bipedal gait, we recorded single-unit activity in the trunk and hindlimb regions of primary motor cortex, supplementary motor area and dorsal premotor cortex of Japanese monkeys walking quadrupedally and bipedally on a treadmill. We found that majority of neurons in all cortical motor areas displayed task-related modulation of activity during quadrupedal and/or bipedal locomotion. However, impacts of transformation of trunk posture from horizontal to vertical on the activity of neurons in each area were strikingly different from those in the other areas. Our results demonstrate that all cortical motor areas examined in monkeys significantly contribute to locomotor control, but possibly in different ways. Our results suggest that cortical mechanisms underpinning bipedal gait are distributed and hierarchically organized and they could provide insight into the pathophysiology of frontal gait disorders in humans.
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Report
(4 results)
Research Products
(15 results)
