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An empirical study on the effects of oxytocin for helping behaviors by marmosets.

Research Project

Project/Area Number 15K13159
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Experimental psychology
Research InstitutionNagoya University

Principal Investigator

KAWAI Nobuyuki  名古屋大学, 情報学研究科, 准教授 (30335062)

Co-Investigator(Renkei-kenkyūsha) ICHINOHE Noritaka  国立研究開発法人国立精神・神経医療研究センター・神経研究所, 微細構造研究部, 部長 (00250598)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsマーモセット / 社会性 / オキシトシン / モデル動物 / 向社会行動
Outline of Final Research Achievements

A preliminary study was conducted to investigate whether marmosets will display helping behavior by obtaining food for other members even if they themselves do not have food, or if their prosocial behavior would be promoted through an oxytocin (OT) injection.
Unlike the previous study, the marmosets did not display helping behavior. Instead, marmosets frequently selected the choice where both the donor and the receiver wouldn’t receive food. As this could constitute as inequality aversion, we investigated whether they display inequality aversion behavior. It was found, for the first time, that both male and female marmosets showed inequality aversion - contrary to conventional studies, while models of autism that were injected with sodium valproate did not show such a behavior.
By measuring OT, cortisol, and other hormones in a non-invasive manner, a method for capturing diurnal variation was securely established, while the models of autism did not display a diurnal variation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Inequity aversion is observed in common marmosets but not in marmoset models of autism induced by prenatal exposure to valproic acid.2018

    • Author(s)
      Yasue M, Nakagami A, Nakagaki K, Ichinohe N, Kawai N
    • Journal Title

      Behav Brain Res.

      Volume: 234 Pages: 36-40

    • DOI

      10.1016/j.bbr.2018.01.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Indifference of marmosets with prenatal valproate exposure to third-party non-reciprocal interactions with otherwise avoided non-reciprocal individuals.2015

    • Author(s)
      Yasue, M., Nakagami, A., Banno, T., Nakagaki, K., Ichinohe, N., Kawai, N.
    • Journal Title

      Behavioural Brain Research

      Volume: 292 Pages: 323-326

    • DOI

      10.1016/j.bbr.2015.06.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Autism-like behaviors in common marmosets treated prenatally with valproic acid.2017

    • Author(s)
      Nobuyuki Kawai
    • Organizer
      New Era of Preclinical Research for Human Diseases using Marmoset (2017 Asia-oceania Regional Meeting for Marmoset Research)
    • Place of Presentation
      Seoul National University Hospital Medical Research Innovation Center (SNUH-CMI), Seo Sung Hwan Research Hall (韓国)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] マーモセットのコルチゾール分泌機能にバルプロ酸が与える影響2017

    • Author(s)
      中神明子, 安江みゆき,中垣慶子,一戸紀孝, 川合伸幸
    • Organizer
      日本心理学会第81回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マーモセットにおける胎生期バルプロ酸暴露と不公平忌避2017

    • Author(s)
      安江みゆき,中神明子,中垣慶子,一戸紀孝, 川合伸幸
    • Organizer
      日本心理学会第81回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胎児期から乳幼児期の学習と記憶2017

    • Author(s)
      川合伸幸
    • Organizer
      第5回新胎児学研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Why does snakes draw our attention more strongly than other animals?2017

    • Author(s)
      Nobuyuki Kawai
    • Organizer
      Evolution of Brain, Cognition, and Emotion
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A new non-invasive method to measure cortisol levels from marmoset.2016

    • Author(s)
      A. Nakagami, M. Yasue, K. Nakagaki, N. Ichinohe, & N. Kawai
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2016-11-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Marmosets with fetal exposure to valproic acid fail to recognize third-party non-reciprocal interactions.2016

    • Author(s)
      N. Kawai, M. Yasue, A. Nakagami, T. Banno, & N. Ichinohe
    • Organizer
      The 31st International Congress of Psychology ICP2016
    • Place of Presentation
      PACIFICO YOKOHAMA(Kanagawa)
    • Year and Date
      2016-07-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 自閉症モデルであるマーモセットは第3者間の互恵的と非互恵的交渉の違いを認識できない2016

    • Author(s)
      安江みゆき, 中神明子, 坂野拓, 一戸紀孝, 川合伸幸
    • Organizer
      電子情報通信学会ヒューマンコミュニケーション基礎(HCS)2016年3月研究会
    • Place of Presentation
      山代温泉 瑠璃光(石川県加賀市)
    • Year and Date
      2016-03-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 「社会行動障害の霊長類モデル作成へむけて」大会企画シンポジウム『社会行動障害への多角的アプローチ-動物からヒト、基礎から臨床-」2015

    • Author(s)
      川合伸幸
    • Organizer
      日本心理学会第79回大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-09-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Marmoset models of autism did not avoid non-reciprocal human individuals.2015

    • Author(s)
      Yasue, M., Nakagami, A., Banno, T., Nakagaki, K., Ichinohe, N., Kawai, N.
    • Organizer
      日本動物心理学会 第75回大会
    • Place of Presentation
      日本女子大学(東京都文京区)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Plasma oxytocin level of male marmoset in pre-and postnatal period.2015

    • Author(s)
      Nakagami, A., Nakagaki, K., Yasue, M., Ichinohe, N., Kawai, N.
    • Organizer
      日本動物心理学会 第75回大会
    • Place of Presentation
      日本女子大学(東京都文京区)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Prenatal exposure to valproic acid (VPA) impairs recognition of third-party social exchanges in marmoset monkeys.2015

    • Author(s)
      Yasue, M., Nakagami, A., Banno, T., Nakagaki, K., Ichinohe, N.,Kawai, N.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場・神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Research-status Report
  • [Presentation] Primate models of autism failed to discriminate third-party reciprocal/non-reciprocal exchange between human actors.2015

    • Author(s)
      Yasue, M., Nakagami, A., Banno, T., Nakagaki, K., Ichinohe, N.,Kawai, N.
    • Organizer
      Tokyo Lectures in Language Evolution
    • Place of Presentation
      東京大学駒場IIキャンパス (東京都文京区)
    • Year and Date
      2015-04-02
    • Related Report
      2015 Research-status Report
  • [Book] 科学の知恵 怒りを鎮める うまく謝る2017

    • Author(s)
      川合 伸幸
    • Total Pages
      224
    • Publisher
      講談社
    • ISBN
      9784062884440
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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