| Project/Area Number |
15K13309
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials engineering
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Miyako Eijiro 国立研究開発法人産業技術総合研究所, ナノ材料研究部門, 主任研究員 (70443231)
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | カーボンナノチューブ / 光発熱特性 / 止血材料 / 近赤外光 |
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| Outline of Final Research Achievements |
We describe a carbon nanotube-liposome-based supramolecular nanohybrid capable of permeation through cells with high biocompatibility. The nanohybrid can be loaded with a variety of functional molecules and is structurally controlled by near-infrared laser irradiation for the release of molecules from the nanohybrids in a targeted manner via microscopy. We implemented the controlled release of molecules from nanohybrids and demonstrated their efficacy in remote regulation of photo-induced nanohybrid functions. As a proof of principle, nanohybrids loaded with amiloride were successfully used in spatiotemporal blocking of targeted amiloride-sensitive mechanosensory neurons in living Caenorhabditis elegans. Our prototype could inspire new designs with biomimetic parasitism and symbiosis and biologically active nanorobots for higher-level manipulation of organisms.
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