Development of Shape Regulatiing methods using MEMS

• Project/Area Number: 15K13319
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nano/Microsystems
• Research Institution: The University of Tokyo
• Principal Investigator: Hirayama Kayoko 東京大学, 大学院情報理工学系研究科, 特任研究員 (60710564)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 大腸菌 / 形状制御 / マイクロナノ加工 / MEMS / 微細加工 / MreB / 細胞壁合成 / ナノ加工

Outline of Final Research Achievements

In this study, I developed a method to deform cellular shape of Escherichia coli by using micro-nano technology. Recent studies identified several proteins which play key role in complex system controlling the shape of E. coli. I fabricated micro chamber and confine E. coli cells into the chamber to see the response of the key proteins of E.coli.