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Single-particle mass pspectroscopy by electrophoresis analyisis

Research Project

Project/Area Number 15K13323
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Nano/Microsystems
Research InstitutionOsaka University

Principal Investigator

Tsutsui Makusu  大阪大学, 産業科学研究所, 准教授 (50546596)

Project Period (FY) 2015-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywordsマイクロナノセンサー
Outline of Final Research Achievements

In this research an integrated nanostructure consisting of micropores, microfluidic channels, and nanoelectrodes were developed to investigate fast electrophoretic dynamics of individual particles in liquid via resistive pulse sensing. Particle translocation time was measured under cross-channel voltage for driving the electrophoretic motions while imposing transverse voltage to the embedded nanoelectrodes. Simultaneous measurements of the longitudinal ionic current and the transverse current showed concomitant change associated with blocking of ion transport via a particle passing through the fluidic channel, thereby demonstrating a possibility of using the novel fluidic channel sensor as a useful tool to study single-particle dynamics in liquid and its application for mass spectroscopy.

Report

(2 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (4 results)

All 2015

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Particle Trajectory-Dependent Ionic Current Blockade in Low-Aspect-Ratio Pores2015

    • Author(s)
      Makusu Tsutsui, Yuhui He, Kazumichi Yokota, Akihide Arima, Sadato Hongo, Masateru Taniguchi, Takashi Washio, Tomoji Kawai
    • Journal Title

      ACS Nano

      Volume: 10 Issue: 1 Pages: 803-809

    • DOI

      10.1021/acsnano.5b05906

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impact of Water-Depletion Layer on Transport in Hydrophobic Nanochannels2015

    • Author(s)
      Yuhui He, Makusu Tsutsui, Xiang Shui Miao, Masateru Taniguchi
    • Journal Title

      Analytical Chemistry

      Volume: 87(24) Issue: 24 Pages: 12040-12050

    • DOI

      10.1021/acs.analchem.5b03061

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Low-aspect-ratio micropore sensors: possibilities and limitations2015

    • Author(s)
      Makusu Tsutsui, Akihide Arima, Kazumichi Yokota, Masateru Taniguchi, Tomoji Kawai
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 四重極マイクロポアによる微粒子通過位置制御2015

    • Author(s)
      筒井真楠,横田一道,谷口正輝, 川合知二
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2017-05-10  

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