| Project/Area Number |
15K13371
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Optical engineering, Photon science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 光コヒーレンストモグラフィー / 光エラストグラフィー / 偏光 / biomechanics / sclera / glaucoma / microscopy / 光コヒーレンストモグラフィー / OCT / 複屈折 / elastography / OCT相関解析 / OCT位相解析 / 光凝固 / 眼球機械特性 |
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| Outline of Final Research Achievements |
A Jones matrix optical coherence elastography (JM-OCE) was developed. This system simultaneously visualize polarization, flow and mechanical properties of biological samples. This system possesses the lateral resolution of 20-30 um and axial resolution of around 7 um, and provides three dimensional topographies of above mentioned tissue properties.
In vitro chicken skins and porcine sclera were investigated by JM-OCE. The chicken skin measurement shows that the epidermis has low birefringence while the dermis has high birefringence. By the porcine scleral measurement, it was found that the sclera has two distinct layers including superficial layer which has layered highly birefringent structures embedded in low birefringent tissue and posterior layer which has homogeneously low-birefringent appearance. Both of the tissue showed stiff appearance in the mechanical contrast images.
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Report
(4 results)
Research Products
(16 results)
