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Optical Rheology

Research Project

Project/Area Number 15K13371
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Optical engineering, Photon science
Research InstitutionUniversity of Tsukuba

Principal Investigator

Yasuno Yoshiaki  筑波大学, 医学医療系, 教授 (10344871)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords光コヒーレンストモグラフィー / 光エラストグラフィー / 偏光 / biomechanics / sclera / glaucoma / microscopy / 光コヒーレンストモグラフィー / OCT / 複屈折 / elastography / OCT相関解析 / OCT位相解析 / 光凝固 / 眼球機械特性
Outline of Final Research Achievements

A Jones matrix optical coherence elastography (JM-OCE) was developed. This system simultaneously visualize polarization, flow and mechanical properties of biological samples. This system possesses the lateral resolution of 20-30 um and axial resolution of around 7 um, and provides three dimensional topographies of above mentioned tissue properties.
In vitro chicken skins and porcine sclera were investigated by JM-OCE. The chicken skin measurement shows that the epidermis has low birefringence while the dermis has high birefringence. By the porcine scleral measurement, it was found that the sclera has two distinct layers including superficial layer which has layered highly birefringent structures embedded in low birefringent tissue and posterior layer which has homogeneously low-birefringent appearance. Both of the tissue showed stiff appearance in the mechanical contrast images.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 10 results,  Acknowledgement Compliant: 3 results) Presentation (5 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Int'l Joint Research] National Chio-Tong University(Republic of China (Taiwan))

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Generation and Optimization of Superpixels as Image Processing Kernels for Jones Matrix Optical Coherence Tomography2017

    • Author(s)
      Arata Miyazawa, Young-Joo Hong, Shuichi Makita, Deepa Kasaragod, and Yoshiaki Yasuno
    • Journal Title

      Biomedical Optics Express

      Volume: 8 Issue: 10 Pages: 4396-4418

    • DOI

      10.1364/boe.8.004396

    • NAID

      120007134736

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Noise-bias and polarization-artifact corrected optical coherence tomography by maximum a-posteriori intensity estimation2017

    • Author(s)
      Aaron Chan, Young-Joo Hong, Shuichi Makita, Masahiro Miura and Yoshiaki Yasuno
    • Journal Title

      Biomedical Optics Express

      Volume: 8 Issue: 4 Pages: 2069-2087

    • DOI

      10.1364/boe.8.002069

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Noise stochastic corrected maximum a posteriori estimator for birefringence imaging using polarization-sensitive optical coherence tomography2017

    • Author(s)
      D EEPA K ASARAGOD , S HUICHI M AKITA , Y OUNG -J OO H ONG , AND Y OSHIAKI Y ASUNO
    • Journal Title

      Biomedical Optics Express

      Volume: 8 Issue: 2 Pages: 653-669

    • DOI

      10.1364/boe.8.000653

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Three-dimensional multi-contrast imaging of in vivo human skin by Jones matrix optical coherence tomography2017

    • Author(s)
      E. Li, S. Makita, Y.-J. Hong, D. Kasaragod, and Y. Yasuno
    • Journal Title

      Biomedical Optics Express

      Volume: 8 Issue: 3 Pages: 1290-1305

    • DOI

      10.1364/boe.8.001290

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Three-dimensional eye motion correction by Lissajous scan optical coherence tomography2017

    • Author(s)
      Yiwei Chen, Young-Joo Hong, Shuichi Makita, and Yoshiaki Yasuno
    • Journal Title

      Biomedical Optics Express

      Volume: 8 Issue: 3 Pages: 1783-1802

    • DOI

      10.1364/boe.8.001783

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Noise-immune complex correlation for optical coherence angiography based on standard and Jones matrix optical coherence tomography2016

    • Author(s)
      S Makita, K Kurokawa, YJ Hong, M Miura, Y Yasuno
    • Journal Title

      Biomed. Opt. Express

      Volume: 7 Issue: 4 Pages: 1525-1548

    • DOI

      10.1364/boe.7.001525

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Maximum posterior estimator for high-contrast image composition of optical coherence tomography2016

    • Author(s)
      AC Chan, K Kurokawa, S Makita, M Miura, Y Yasuno
    • Journal Title

      Optic Letter

      Volume: 41 Issue: 2 Pages: 321-324

    • DOI

      10.1364/ol.41.000321

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In-plane and out-of-plane tissue micro-displacement measurement by correlation coefficients of optical coherence tomography2015

    • Author(s)
      Kazuhiro Kurokawa, Shuichi Makita, Young-Joo Hong, Yoshiaki Yasuno
    • Journal Title

      Optics Letters

      Volume: 40 Issue: 9 Pages: 2153-2156

    • DOI

      10.1364/ol.40.002153

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo photothermal optical coherence tomography for non-invasive imaging of endogenous absorption agents2015

    • Author(s)
      S. Makita and Y. Yasuno
    • Journal Title

      Biomed. Opt. Express

      Volume: 6 Issue: 5 Pages: 1707-1725

    • DOI

      10.1364/boe.6.001707

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography2015

    • Author(s)
      S Sugiyama, YJ Hong, D Kasaragod, S Makita, S Uematsu, Y Ikuno, M Miura , Y Yasuno
    • Journal Title

      Biomed. Opt. Express

      Volume: 6 Issue: 12 Pages: 4951-4974

    • DOI

      10.1364/boe.6.004951

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Photocoagulation laser control using phase-sensitive optical coherence tomography toward laser lesion management2018

    • Author(s)
      En Li,S.Makita and Y.Yasuno
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Imaging conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simultaneous tissue birefringence and deformation measurement by polarization sensitive optical coherence elastography with active compression2018

    • Author(s)
      En Li,Shuichi Makita,Deepa Kasaragod and Yoshiaki Yasuno
    • Organizer
      BiOS, SPIE Photonics West
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Jones matrix formalism of polarization sensitive OCT andapplication to retinal investigation2018

    • Author(s)
      Yoshiaki Yasuno
    • Organizer
      The CBORT symposium on Advances in Biomedical Polarimetry with Optical Coherence tomography
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 偏光で見るバイオメカニクス - 偏光OCT と OCT エラストグラフィー2018

    • Author(s)
      安野嘉晃
    • Organizer
      第65回応用物理学会春季講演会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Birefringence and deformation estimation of biological tissue by polarization sensitive optical coherence elastography2017

    • Author(s)
      En Li, Shuichi Makita,Deepa Kasaragod,Yoshimi Iwasaki and Yoshiaki Yasuno
    • Organizer
      Optics Photonics japan
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2022-08-18  

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