Multi-frequency force modulation AFM: Mapping single cell rheological parameters
| Project/Area Number |
15K13393
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General applied physics
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUEOKA KAZUHISA 北海道大学, 情報科学研究科, 教授 (60250479)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 原子間力顕微鏡 / 細胞レオロジー |
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| Outline of Final Research Achievements |
In this study, I developed multi-frequency force modulation atomic force microscopy (AFM) which enable mapping rheological properties of living cells in their physiological conditions. The AFM method was applied to investigate (1) the relationship between cell rheology and cell cytoskeleton at the single cell level, (2) single cancer cell mechanical diagnostics, and (3) ensemble and temporal variations of single cell rheology.
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Report
(3 results)
Research Products
(12 results)
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[Presentation] Diagnosing single cell diseases by SPM2016
Author(s)
M. Sawano*, K. Aoki, R. Tanaka, K. Kuribayashi-Shigetomi, A. Subagyo, K. Sueoka, N.J. Cho, T. Okajima
Organizer
24th International Colloquium on Scanning Probe Microscopy (ICSPM24)
Place of Presentation
Hawaii(Hawaii Convention Center)
Year and Date
2016-12-14
Related Report
Int'l Joint Research
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