• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation of healthiness by in vivo broadband dielectric spectroscopy for water structures in living body

Research Project

Project/Area Number 15K13554
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biological physics/Chemical physics/Soft matter physics
Research InstitutionTokai University

Principal Investigator

Yagihara Shin  東海大学, 理学部, 教授 (40191093)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsWater structure / Dielectric spectroscopy / Broadband dynamics / Living body / in vivo / Noninvasive testing / free water / Interfacial polaization / 水構造 / 広帯域誘電分光 / BDS / 非侵襲計測 / 誘電緩和 / 界面分極 / フラクタル / 水素結合ネットワーク / in vivo 広帯域誘電分光 / 非侵襲誘電測定 / 磁場勾配核磁気共鳴法 / フラクタル水構造解析 / 培養細胞 / リポソーム / モデルマウス
Outline of Final Research Achievements

Water structure analysis was performed for biological tissue models, such as standard liquids, ionic water flow, polymer gels, and emulsions, using broadband dielectric spectroscopy (BDS) and complementary techniques such as nuclear magnetic resonance and molecular dynamic simulation. The fractal analysis of dynamic hydrogen bonding network by BDS offers the water content, restrictions and dispersion of water molecules and ions. Furthermore, applications to cultured cells, organs from model mice, and the noninvasive test make it possible to distinguish organs obtained from robust and septic mice, respectively, and suggest a possibility of new bioinstrumentations and analytical methods. In future, applications should be expected in various areas of brain functions, medical care, and extensive areas of natural science and technology.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (27 results)

All 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results,  Open Access: 1 results,  Acknowledgement Compliant: 7 results) Presentation (11 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] ヘブライ大学(イスラエル)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] アテネ工科大学(ギリシャ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Galgotias University(インド)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Electrocapillary Phenomena at Edible Oil/Saline Interfaces2017

    • Author(s)
      Satoshi Nishimura, Takuya Ohzono, Kohei Shoji, Shin Yagihara, Masahumi Hayashi, Hisao Tanaka
    • Journal Title

      Journal of Oleo Science

      Volume: 66 Issue: 3 Pages: 235-249

    • DOI

      10.5650/jos.ess16182

    • NAID

      130005397225

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dielectric study on hierarchical water structures restricted in cement and wood materials2017

    • Author(s)
      Fumiya Abe, Akihiro Nishi, Hironobu Saito, Megumi Asano, Seiei Watanabe, Rio Kita, Naoki Shinyashiki, ShiSeiichi Sudo, Youki Suzuki
    • Journal Title

      Measurement Science and Technology

      Volume: 28 (4) Issue: 4 Pages: 046601-046601

    • DOI

      10.1088/0034-4885/76/4/046601

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Elbow- and hinge-bending motions of IgG: Dielectric response and dynamic feature2016

    • Author(s)
      Yoshihito Hayashi and Shin. Yagihara
    • Journal Title

      Biopolymers

      Volume: 印刷中 Issue: 9 Pages: 626-632

    • DOI

      10.1002/bip.22841

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Bi-modality Diffusion of Water Molecules in Liposome/Water Dispersion Systems Analyzed by Pulsed Field Gradient Spin Echo NMR Method2016

    • Author(s)
      Tsubasa Kawaguchi, Rio Kita, Naoki Shinyashiki, Shin Yagihara, Minoru Fukuzaki
    • Journal Title

      Transactions of the Materials Research Society of Japan

      Volume: 41 Issue: 4 Pages: 359-362

    • DOI

      10.14723/tmrsj.41.359

    • NAID

      130005172509

    • ISSN
      1382-3469, 2188-1650
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dynamics of Uncrystallized Water, Ice, and Hydrated Protein in Partially Crystallized Gelatin-Water Mixtures Studied by Broadband Dielectric Spectroscopy2016

    • Author(s)
      Kaito Sasaki, Anna Panagopoulou, Rio Kita, Naoki Shinyashiki, Shin Yagihara, Apostolos Kyritsis, Polycarpos Pissis
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 121 (1) Issue: 1 Pages: 265-272

    • DOI

      10.1021/acs.jpcb.6b04756

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dielectric Relaxation Time of Ice Ih with Different Preparation2016

    • Author(s)
      Kaito Sasaki, Rio Kita, Naoki Shinyashiki, and Shin Yagihara
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 印刷中 Issue: 16 Pages: 3950-3953

    • DOI

      10.1021/acs.jpcb.6b01218

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dielectric study on temperature-concentration superposition of liquid to glass in fructose-water mixtures2015

    • Author(s)
      Wataru Yamamoto, Kaito Sasaki, Rio Kita, Shin Yagihara, Naoki Shinyashiki
    • Journal Title

      Journal of Molecular Liquids

      Volume: 206 Pages: 39-46

    • DOI

      10.1016/j.molliq.2015.01.057

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Relaxation dynamics of liposomes in an aqueous solution2015

    • Author(s)
      S. K. Kundu, S. Choe, K. Sasaki, R. Kita, N. Shinyashiki, and S. Yagihara
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 17(28) Issue: 28 Pages: 18449-55

    • DOI

      10.1039/c5cp01334h

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of Water Measurement Techniques for Human Skin by Dielectric Spectroscopy and Confocal Raman Spectroscopy2015

    • Author(s)
      S. Sato, Y. Maruyama, H. Kamata, S. Watanabe. R. Kita, N. Shinyashiki, S. Yagihara, M. Egawa, and N. Kunizawa
    • Journal Title

      Transactions of the Materials Research Society of Japan

      Volume: 40 Issue: 2 Pages: 133-136

    • DOI

      10.14723/tmrsj.40.133

    • NAID

      130005089530

    • ISSN
      1382-3469, 2188-1650
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soret effect of aqueous solutions of ethylene glycol oligomers, crown ethers, and glycerol: Temperature, molecular weight, and hydrogen bond effect2015

    • Author(s)
      Kousaku Maeda, Naoki Shinyashiki, Shin Yagihara, Simone Wiegand, and Rio Kita
    • Journal Title

      The Journal of Chemical Physics

      Volume: 143(12) Issue: 12 Pages: 124504-124504

    • DOI

      10.1063/1.4931115

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 非侵襲誘電分光法による生体測定における血液の影響評価2016

    • Author(s)
      齋藤徹哉、浅野晴香、斉藤宏伸、喜多理王、新屋敷直木、八木原晋
    • Organizer
      第26回日本MRS年次大会
    • Place of Presentation
      横浜情報文化センター(横浜)
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 食用油の分子挙動と水との凝集構造形成への誘電分光法からの考察2016

    • Author(s)
      庄司幸平、齋藤徹哉、喜多理王、新屋敷直木、八木原晋、福崎稔、大園拓哉、西村聡、林正史、田中久雄
    • Organizer
      第26回日本MRS年次大会
    • Place of Presentation
      横浜情報文化センター(横浜)
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞分散系のPFG-NMRと誘電分光による膜損傷に伴う水とイオンの運動性の変化2016

    • Author(s)
      青山剛志、斉藤宏伸、川口翼、喜多理王、新屋敷直木、八木原晋、福崎稔、伊藤敦、浅見耕司
    • Organizer
      第55回NMR討論会
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dielectric Study on Dynamics of Water Molecules and Ions Restricted in Cement and Wood Materials2016

    • Author(s)
      Shin Yagihara, Fumiya Abe, Akihiro Nishi, Hironobu Saito, Megumi Asano, Seiei Watanabe, Rio Kita, Naoki Shinyashiki, Minoru Fukuzaki, Seiichi Sudo, Youki Suzuki
    • Organizer
      11th International Conference on Electromagnetic Wave Interaction with Water and Moist Substances
    • Place of Presentation
      Congress Center of the National Research Council of Sesto Fiorentino (Firenze, Italy)
    • Year and Date
      2016-05-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Observation and Complementary Analysis for Water Dynamics of Tofu Gel using PFG-NMR and Dielectric Spectroscopy2016

    • Author(s)
      Tsubasa Kawaguchi, Rio Kita, Naoki Shinyashiki, Shin Yagihara, Minoru Fukuzaki
    • Organizer
      11th International Conference on Electromagnetic Wave Interaction with Water and Moist Substances
    • Place of Presentation
      Congress Center of the National Research Council of Sesto Fiorentino (Firenze, Italy)
    • Year and Date
      2016-05-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 敗血症および水素水がマウス臓器の水構造に与える影響2015

    • Author(s)
      青山剛志、川口翼、齋藤徹哉、清水健太、庄司幸平、八木原晋、新屋敷直木、喜多理王、福崎稔、増田治史
    • Organizer
      第53回高分子と水に関する討論会
    • Place of Presentation
      目黒,東京
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 傾斜磁場勾配法を用いた31P,2H-NMRによるリポソーム/水分散系における拡散現象2015

    • Author(s)
      川口翼、喜多理王、新屋敷直木、八木原晋、福﨑稔
    • Organizer
      第25回日本MRS年次大会
    • Place of Presentation
      横浜,神奈川
    • Year and Date
      2015-12-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 広域誘電分光法を用いた高分子生体素材中の水2015

    • Author(s)
      斉藤宏伸、佐藤駿介、喜多理王、新屋敷直木、八木原晋、福﨑稔、望月明、田中賢
    • Organizer
      第25回日本MRS年次大会
    • Place of Presentation
      横浜,神奈川
    • Year and Date
      2015-12-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 懸濁液中の細胞構造に由来する誘電緩和過程2015

    • Author(s)
      青山剛志、斉藤宏伸、川口翼、清水健太、八木原晋、新屋敷直木、喜多理王、福崎稔、浅見耕司
    • Organizer
      第25回日本MRS年次大会
    • Place of Presentation
      横浜,神奈川
    • Year and Date
      2015-12-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 水素結合している水分子の大規模挙動2015

    • Author(s)
      八木原晋、喜多理王、新屋敷直木、福﨑稔
    • Organizer
      第25回日本MRS年次大会
    • Place of Presentation
      横浜,神奈川
    • Year and Date
      2015-12-09
    • Related Report
      2015 Research-status Report
  • [Presentation] フィリングインに対する前頭葉のNIRS測定

    • Author(s)
      田窪洸祐,八木原晋,新屋敷直木,喜多理王,佐藤駿介,川口翼,栗田太作,福﨑稔,灰田宗孝,大橋三男
    • Organizer
      第25回日本MRS年次大会
    • Place of Presentation
      横浜,神奈川
    • Related Report
      2015 Research-status Report
  • [Book] Chapter 8 in Nano/Micro Science and Technology in Biorheology: Principles, Methods, and Applications (Eds. T. Dobashi and R. KIta)2015

    • Author(s)
      S. Yagihara
    • Total Pages
      443
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Remarks] 水 - 物質・生命のうつし絵 -

    • URL

      http://www.sp.u-tokai.ac.jp/~ylab/aim_yagihara.htm

    • Related Report
      2016 Annual Research Report
  • [Remarks] 水構造ダイナミクスの意味と現代科学

    • URL

      https://sites.google.com/view/waterstructures

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi