Evaluation of healthiness by in vivo broadband dielectric spectroscopy for water structures in living body
| Project/Area Number |
15K13554
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Water structure / Dielectric spectroscopy / Broadband dynamics / Living body / in vivo / Noninvasive testing / free water / Interfacial polaization / 水構造 / 広帯域誘電分光 / BDS / 非侵襲計測 / 誘電緩和 / 界面分極 / フラクタル / 水素結合ネットワーク / in vivo 広帯域誘電分光 / 非侵襲誘電測定 / 磁場勾配核磁気共鳴法 / フラクタル水構造解析 / 培養細胞 / リポソーム / モデルマウス |
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| Outline of Final Research Achievements |
Water structure analysis was performed for biological tissue models, such as standard liquids, ionic water flow, polymer gels, and emulsions, using broadband dielectric spectroscopy (BDS) and complementary techniques such as nuclear magnetic resonance and molecular dynamic simulation. The fractal analysis of dynamic hydrogen bonding network by BDS offers the water content, restrictions and dispersion of water molecules and ions. Furthermore, applications to cultured cells, organs from model mice, and the noninvasive test make it possible to distinguish organs obtained from robust and septic mice, respectively, and suggest a possibility of new bioinstrumentations and analytical methods. In future, applications should be expected in various areas of brain functions, medical care, and extensive areas of natural science and technology.
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Report
(3 results)
Research Products
(27 results)
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[Presentation] Dielectric Study on Dynamics of Water Molecules and Ions Restricted in Cement and Wood Materials2016
Author(s)
Shin Yagihara, Fumiya Abe, Akihiro Nishi, Hironobu Saito, Megumi Asano, Seiei Watanabe, Rio Kita, Naoki Shinyashiki, Minoru Fukuzaki, Seiichi Sudo, Youki Suzuki
Organizer
11th International Conference on Electromagnetic Wave Interaction with Water and Moist Substances
Place of Presentation
Congress Center of the National Research Council of Sesto Fiorentino (Firenze, Italy)
Year and Date
2016-05-23
Related Report
Int'l Joint Research
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