| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
In this study, we aimed to modify red blood cell cytoskeletons with metal complexes. We have succeeded in the synthesis of NHS ester derivatives of metal ligands, the optimization of reaction conditions between NHS ester derivatives of metal ligands and ghost Red Blood Cell (gRBC), and the formation of metal complexes on the cytoskeleton of gRBC modified with metal ligands. These results showed that the cytoskeleton of gRBC provided a useful platform for immobilization of metal complexes. Further efforts are in progress to elucidate the detail structure of gRBC cytoskeleton modified with metal complexes, and the physical properties of metal complexes on gRBC cytoskeleton.
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