Functionalization of cytoskeletons by metal complexes
Project/Area Number |
15K13661
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Inorganic chemistry
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Research Institution | Kyushu University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 細胞膜骨格 / 赤血球 / 金属錯体 / 外部刺激応答性 |
Outline of Final Research Achievements |
In this study, we aimed to modify red blood cell cytoskeletons with metal complexes. We have succeeded in the synthesis of NHS ester derivatives of metal ligands, the optimization of reaction conditions between NHS ester derivatives of metal ligands and ghost Red Blood Cell (gRBC), and the formation of metal complexes on the cytoskeleton of gRBC modified with metal ligands. These results showed that the cytoskeleton of gRBC provided a useful platform for immobilization of metal complexes. Further efforts are in progress to elucidate the detail structure of gRBC cytoskeleton modified with metal complexes, and the physical properties of metal complexes on gRBC cytoskeleton.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Regulation of Cerium(IV)-driven O2 Evolution Reaction using Composites of Liposome and Lipophilic Ruthenium Complexes2015
Author(s)
Tomomi Koshiyama, Nao Kanda, Koki Iwata, Masayuki Honjo, Sana Asada, Tatsuru Hatae, Yasuhiro Tsuji, Masaki Yoshida, Masaya Okamura, Reiko Kuga, Shigeyuki Masaoka, Masaaki Ohba
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Journal Title
Dalton Trans.
Volume: 44
Issue: 34
Pages: 15126-15129
DOI
Related Report
Peer Reviewed
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