| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
The purpose of this research is development of highly challenging catalytic enantioselective hydrofluorination and hydrotrifluoromethylation of alkenes. While preliminary, we have developed a nonenantioselective copper-based catalyst system for the catalytic hydrofluorination of alkenes. To increase the catalytic performance and establish the enantioselective variant, we have also developed a new copper-catalyzed C-P bond-forming reaction for the synthesis of novel and highly active ligands. By this Cu catalysis, we can obtain bisphosphine-type ligands from simple and readily available terminal alkenes in one shot.
|
