Challenge for Development of Catalytic Enantioselective Hydrofluorination and Hydrotrifluoromethylation of Alkenes
| Project/Area Number |
15K13696
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Hirano Koji 大阪大学, 工学研究科, 准教授 (70532696)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | フッ素 / 銅触媒 / リン / 触媒的不斉合成 / 有機フッ素化合物 / 有機リン化合物 |
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| Outline of Final Research Achievements |
The purpose of this research is development of highly challenging catalytic enantioselective hydrofluorination and hydrotrifluoromethylation of alkenes. While preliminary, we have developed a nonenantioselective copper-based catalyst system for the catalytic hydrofluorination of alkenes. To increase the catalytic performance and establish the enantioselective variant, we have also developed a new copper-catalyzed C-P bond-forming reaction for the synthesis of novel and highly active ligands. By this Cu catalysis, we can obtain bisphosphine-type ligands from simple and readily available terminal alkenes in one shot.
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Report
(3 results)
Research Products
(25 results)
