Synthetic Study on Chirality Control with Circular Polarized Microwave
| Project/Area Number |
15K13700
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Keio University |
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Principal Investigator |
Yamada Tohru 慶應義塾大学, 理工学部(矢上), 教授 (40296752)
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| Co-Investigator(Kenkyū-buntansha) |
今枝 健一 中部大学, 工学部, 教授 (60314085)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | キラリティ / マイクロ波 / 円偏波 / 不斉還元 / 軸不斉 / 触媒的不斉合成反応 / キラリティー / 円偏波マイクロ波 |
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| Outline of Final Research Achievements |
The effect of circularly polarized microwave irradiation was examined. Substrate was charged, without irradiation, or under right-handed / left-handed CPM irradiation, and the ee of the reduced product was analyzed. When the asymmetric catalysis was irradiated with 12.4 GHz CPM, the ee under the right-handed conditions was improved more than the non-irradiated conditions, but decreased in the left-handed conditions. In the 2.45 GHz / 50 W CPM irradiation to the racemic catalytic reaction, both the right-handed and the left-handed conditions improved, and the microwave effect should be considered.
The CPM effect on atropo-isomerization reaction was examined. After 2.45 GHz / 20 W CPM irradiation, the ee was analyzed after reduction to prevent from racemization. As a result of the statistical processing, we found reaction conditions that the enantiomeric excess was observed in the opposite directions on the left-handed and the right-handed, though in the racemic 95% confidence interval.
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Report
(3 results)
Research Products
(16 results)
