| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
We examined the reaction of 2,3,3-trifluoroallylic esters with several nucleophiles, such as nitrogen, oxygen, or carbon nucleophiles, by palladium catalysts, then we succeeded in progressing the new types of reactions, which provides trifluoromethyl group possessing organic compounds, which were produced by the attack of nucleophiles on to C-2 position of allylic group, and sequential intramolecular fluorine atom shift. We further demonstrated this types of palladium-catalyzed reaction with several types of nucleophiles, and succeeded in obtaining several types of trifluoromethylenamines, trifluoromethyl group containing 3-substituted indole analogues, or trifluoromethyl group possessing enol ethers.
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