Micro Chmical modification tool for region selective surface treatment

• Project/Area Number: 15K13731
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Analytical chemistry
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: Uchiyama Katsumi 首都大学東京, 都市環境科学研究科, 教授 (40151899)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 微小化学反応描画ツール / ケミカルファブリケーション / 微小化学描画 / 微小化学反応 / 微細化学描画 / マイクロ流体 / マイクロ・ナノパターニング

Outline of Final Research Achievements

Various micro/nano surface-modification techniques such as photolithography, dip-pen lithography and micro-fluidic systems have been developed. And they were used to extend the functionalities of solid surfaces. While those approaches work in the “open space”, push&/pull systems which work in solutions have recently drawn considerable attention. While microscale, region-selective chemical reactions have remained unattainable. This work reports a micro-chemical pen that enables region-selective chemical reactions for the micro/nano surface modification. The chemical pen is based on the principle of microfluidic laminar flows. The micro scale diffusion layer performs as the working region of the surface modification. This work is the first demonstration of an open micro reactor. The characteristics of the micro chemical pen are confirmed by different types of reactions, including inorganic chemistry, polymer science, electrochemistry and biological sample treatment.

Research Products

• [Int'l Joint Research] Department of Chemistry/Tsinghua University(China)
• [Journal Article] Microchemical Pen: An Open Microreactor for Region-Selective Surface Modification (2016)
  • Author(s): S. Mao, C. Sato, Y. Suzuki, J. Yang, H. Zeng, H. Nakajima, M. Yang, J-M. Lin, K. Uhciyama
  • Journal Title: ChemPhysChem Volume: 17 Issue: 20 Pages: 3155-3159
  • DOI: 10.1002/cphc.201600857
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] インクジェットによる超微小液滴生成とクロマトグラフィーへの応用 (2016)
  • Author(s): 内山一美
  • Journal Title: 分析化学 Volume: 65 Pages: 1-11
  • NAID: 130005124375
  • Peer Reviewed
• [Journal Article] マルチビームスプリッターを用いる二次元表面プラズモン共鳴センサーによる多成分同時イムノアッセイの検討 (2015)
  • Author(s): 森岡和大, 中嶋秀, 辺見彰秀, 飯田慎平, 北村 文, 曽 湖烈, 加藤俊吾, 内山一美
  • Journal Title: 分析化学 Volume: 65 Pages: 79-85
  • NAID: 130005131107
  • Peer Reviewed
• [Journal Article] Quantitative on-line concentration for capillary electrophoresis with inkjet sample introduction technique (2015)
  • Author(s): Y. Rang, H. Zeng, H. Nakajima, S. Kato, K. Uchiyama
  • Journal Title: Journal of separation Sciences Volume: 38 Pages: 2722-2728
  • Peer Reviewed
• [Journal Article] Investigation of monodisperse droplet generation in liquids by inkjet (2015)
  • Author(s): H. Zeng, J. Yang, D. Katagiri, Y. Rang, S. Xue, H. Nakajima, K. Uchiyama
  • Journal Title: Sensors and Actuators B Volume: 220 Pages: 958-961
  • Peer Reviewed
• [Presentation] マイクロ化学ペンによるナノ・マイクロ化学構造外の作製 (2017)
  • Author(s): 内山一美
  • Organizer: 化学センサ研究会
  • Place of Presentation: 首都大学東京(東京都八王子市)
  • Year and Date: 2017-03-25
  • Invited
• [Presentation] μ/nano-chemical pen and new digital PCR (2017)
  • Author(s): Katsumi Uchiyama
  • Organizer: Colloquim on analytical chemistry
  • Place of Presentation: Beijing (China)
  • Int'l Joint Research / Invited
• [Presentation] マイクロ流体をベースとした化学ペン (2016)
  • Author(s): 毛思鋒，佐藤知穂，鈴木雄馬，楊建民，曾湖烈，中嶋秀，楊明，林金明，内山一美
  • Organizer: 有機微量分析研究懇談会
  • Place of Presentation: アイーナ（岩手県盛岡市)
  • Year and Date: 2016-05-26
• [Presentation] Drop-by-drop chemical reaction and sample introduction for capillary electrophoresis (2015)
  • Author(s): Katsumi Uchiyama
  • Organizer: The 16th Beijing conference and exhibition on instrumental analysis
  • Place of Presentation: Beijin, China
  • Year and Date: 2015-10-28
  • Int'l Joint Research / Invited
• [Presentation] Quantitative on-line Concentration and Reaction for Capillary Electrophoresis with Inkjet Sample Introduction (2015)
  • Author(s): Y. Rang, F. Chen, H. Zeng, H. Nakajima, S. Kato, J-M. Lin, K. Uchiyama
  • Organizer: 2015 China-Japan=Korea Symposium on analytical Chemistry
  • Place of Presentation: Busan, Korea
  • Year and Date: 2015-10-13
  • Int'l Joint Research / Invited
• [Presentation] Mirofluidic based chemical pen (2015)
  • Author(s): S. Mao, C. Sato, H. Zeng, H. Nakajima, K. Uchiyama
  • Organizer: The 8th international forum on chemistry of functional organic chemicals
  • Place of Presentation: Tokyo University
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Remarks] 内山研究室
  • URL: http://www.comp.tmu.ac.jp/uchiyama/
• [Remarks] 環境分析化学研究室(内山研究室)
  • URL: http://www.comp.tmu.ac.jp/uchiyama/