Fine chemical synthesis of poly(ADP-ribose) for disease studies
| Project/Area Number |
15K13736
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Okamoto Akimitsu 東京大学, 先端科学技術研究センター, 教授 (60314233)
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | ポリADP-リボース / 化学合成 / 固相合成 / ADP / リボース |
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| Outline of Final Research Achievements |
This research project was carried out for a year in FY2015. In this year we established the efficient synthetic process of poly(ADP-ribose). Because of the short research term, we concentrated to the synthesis of a linear poly(ADP-ribose) and explored the best suited reaction conditions. Based on a phosphoramidite process, one of DNA solid support synthesis, we created a new chemical synthesis of poly(ADP-ribose). Ribosyladenosine was protected with a dimethoxytrityl group for a hydroxy group to be linked with another building block and benzoyl groups for a the other hydroxy groups. In addition, a ribose unit for a starter and a adenosine unit for a capping were also prepared. We obtained a ADP-ribose dimer through a synthetic cycle.
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Report
(2 results)
Research Products
(1 results)
