Studies toward a synthesis of virus capsids

• Project/Area Number: 15K13786
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Polymer/Textile materials
• Research Institution: Kyoto University
• Principal Investigator: Chihiro Tsukano 京都大学, 薬学研究科, 講師 (70524255)
• Co-Investigator(Renkei-kenkyūsha): OISHI Shinya 京都大学, 大学院薬学研究科, 准教授 (80381739)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: キャプシド / 合成化学 / 化学合成

Outline of Final Research Achievements

A synthesis of a virus capsid of RNA pharge MS2 has been investigated. The three fragments were synthesized for the capsid.

Research Products

• [Journal Article] Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-catalyzed Intramolecular Amidation of a Vinyl Iodide (2016)
  • Author(s): 中村斐有、吉田拓馬、塚野千尋、竹本佳司
  • Journal Title: Organic Letters Volume: 18 Issue: 9 Pages: 2300-2303
  • DOI: 10.1021/acs.orglett.6b00943
  • NAID: 120006547379
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthetic Studies towards Communesins: Diastereoselective Oxidative Rearrangement of Aurantioclavine Derivatives (2016)
  • Author(s): Suetsugu, S.; Tsukano, C.; Takemoto, Y.*
  • Journal Title: Eur. J. Org. Chem. Volume: 2016 Issue: 1 Pages: 108-115
  • DOI: 10.1002/ejoc.201501194
  • NAID: 120006547382
  • Peer Reviewed
• [Journal Article] Synthesis of α-Acyloxyketone Derivatives <i>via</i> the Platinum-Catalyzed Migration of Propargylic Esters (2015)
  • Author(s): Tsukano, C.; Yamamoto, S.; Takemoto, Y.*
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 63 Issue: 9 Pages: 710-719
  • DOI: 10.1248/cpb.c15-00417
  • NAID: 130005096033
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access
• [Presentation] CPZEN-45の全合成 (2016)
  • Author(s): 塚野千尋、中村斐有、吉田拓馬、竹本佳司
  • Organizer: 第110回有機合成シンポジウム
  • Place of Presentation: 早稲田大学国際会議場、東京都新宿区
  • Year and Date: 2016-11-10
• [Presentation] パラジウム触媒反応および脱芳香環化を基軸とした複雑な生物活性天然物の全合成 (2016)
  • Author(s): 塚野千尋
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-03-27
  • Invited
• [Presentation] Palladium-Catalyzed Amidation by Chemoselective C(sp3)-H functionalization: Concise Route to Oxindoles and its application (2015)
  • Author(s): 2.〇Chihiro Tsukano, Masataka, Okuno, Takeshi Nanjo, Nobusuke Muto, Yoshiji Takemoto
  • Organizer: The 25th ISHC Congress
  • Place of Presentation: University of California, Santa barbara (USA)
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Remarks] 所属研究室での発表論文
  • URL: http://www.pharm.kyoto-u.ac.jp/orgchem/04_ron.html
• [Remarks] 所属研究室での学会発表
  • URL: http://www.pharm.kyoto-u.ac.jp/orgchem/05_gak.html