Living functional hydrogels generated by bioorthogonal cross-linking reactions of azide-modified cells with alkyne-modified polymers
| Project/Area Number |
15K13791
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer/Textile materials
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| Research Institution | Konan University |
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Principal Investigator |
NAGAHAMA Koji 甲南大学, フロンティアサイエンス学部, 准教授 (00551847)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ハイドロゲル / 細胞 / バイオマテリアル / 再生医療 / 高分子 / 機能性材料 / 刺激応答ゲル / 機能性ハイドロゲル / 細胞表面クリック反応 / 細胞機能利用 |
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| Outline of Final Research Achievements |
In this study, we show a concept for utilizing cells and their functions from the viewpoint of materials science. In particular, we develop cell cross-linked living bulk hydrogels by bioorthogonal click cross-linking reactions of azide-modified mammalian cells with alkyne-modified biocompatible polymers. Importantly, we demonstrate the unique functionalities of the living hydrogels, originating from the basic functions of the cells incorporated in the living hydrogels as active cross-linking points. Moreover, we demonstrate potential application of the cell cross-linked hydrogels as injectable gels for tissue engineering. As this method can be applied to bacteria and viruses because their surfaces can be modified by metabolic glycoengineering, the findings of this study provide a promising route to the generation of living cell-based next-generation innovative materials, technologies, and medicines.
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Report
(4 results)
Research Products
(15 results)
