| Project/Area Number |
15K13809
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Inorganic industrial materials
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMOJIMA Atsushi 早稲田大学, 理工学術院, 教授 (90130872)
TAKEOKA Shinji 早稲田大学, 理工学術院, 教授 (20222094)
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| Research Collaborator |
OBA Yuki
NAGATA Koya
HIROOKA Naoko
FUJIWARA Minekazu
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | メソポーラスシリカナノ粒子 / バイオイメージング / 温度応答性色素 / 中空ナノ粒子 / 外表面被覆 |
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| Outline of Final Research Achievements |
Colloidal mesoporous silica nanoparticles (CMS) as bioimaging carriers possessing various internal nanospaces were prepared and the pore clogging of outer surfaces of CMS was successfully realized. The pore size of CMS was controlled in the range from 4 nm to 8 nm using controlled templating. Hollow siloxane-based nanoparticles with high colloidal stability were also prepared when CMS were covered with ethenylene-bridged organosiloxane. The outer surfaces of CMS containing thermoresponsive dyes were successfully covered by the simple addition of tetraalkoxysilane under controlled pH conditions. The thermally responsible property of the dye in the internal nanospace of CMS was retained after the pore clogging.
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