Study on the manipulation of microbubble-encapsulated vesicles using ultrasound field
| Project/Area Number |
15K13865
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fluid engineering
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKAGI SHU 東京大学, 大学院工学系研究科(工学部), 教授 (30272371)
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| Co-Investigator(Kenkyū-buntansha) |
杵淵 郁也 東京大学, 大学院工学系研究科(工学部), 講師 (30456165)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 混相流 / マイクロバブル / 超音波 / DDS / ベシクル / 表面修飾 / マイクロチャネル / バブルクラスター / ドラッグデリバリーシステム / ビヤクネス力 / 脂質膜 / 膜破壊 |
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| Outline of Final Research Achievements |
In this study, for the application of micro bubble DDS, we investigated the efficient method to generate microbubble-encapsulated vesicles. We further investigated the method to control the vesicle position and to break-up the vesicle membrane using ultrasound field. Both the experiments and simulations were conducted for the manipulation of vesicles. As results, it was shown that microbubble-encapsulated vesicles are very effectively generated by introducing Oil/Water Interface inverted emulsion method. For the vesicle manipulations, we succeeded to break-up the vesicles by manipulating bubbles using ultrasound field. The simulations were conducted to investigate the bubble size effect to the effective break-up of the vesicles.
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Report
(3 results)
Research Products
(7 results)
