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Creation of microfluidic and transportation devices using earthworm muscle

Research Project

Project/Area Number 15K13919
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Tanaka Yo  国立研究開発法人理化学研究所, 生命機能科学研究センター, ユニットリーダー (40532271)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsマイクロ・ナノデバイス / マイクロマシン / 流体工学 / 生物機能利用 / 筋肉 / ミミズ / ポンプ / バルブ / 生体機能利用
Outline of Final Research Achievements

Miniaturization of pumps and valves are required in many fields, but there has been a limit due to the electric power source and wire in case of using conventional machine engineering. Here, we use muscle tissue that has no such issues, and developed an earthworm muscle based small pump. By using microfabrication technique, a microchannels and chamber was fabricated. The earthworm muscle was fixed on it. Fluid pumping was confirmed when electric pulse stimulation was added. In a similar structure with a system completely clogging the channel by a membrane due to the muscle contraction, a valve was created. Earthworm based robots were also created.

Academic Significance and Societal Importance of the Research Achievements

今回試作したデバイスは、動作のためのエネルギー源はアデノシン三リン酸(ATP)である。神経組織なども含めて、人工的にミミズと同様の構造を作ることができれば、電気なしでも使える可能性があることから、本成果、超微小デバイスを開発していく上でのモデルになると考えられる。今後、より人工的なアクチュエータとして工学ないし医療など様々な用途に使えるものに発展させられることが期待される。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results) Remarks (3 results) Funded Workshop (1 results)

  • [Int'l Joint Research] スイス連邦工科大学(スイス)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A valve powered by earthworm muscle with both electrical and 100% chemical control2019

    • Author(s)
      Yo Tanaka, Shun-ichi Funano, Yuji Noguchi, Yaxiaer Yalikun, Norihiro Kamamichi
    • Journal Title

      Scientific Reports

      Volume: - Issue: 1 Pages: 8042-8042

    • DOI

      10.1038/s41598-019-44116-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An ultra-small fluid oscillation unit for pumping driven by self-organized three-dimensional bridging of pulsatile cardiomyocytes on elastic micro-piers2019

    • Author(s)
      Nobuyuki Tanaka, Tadahiro Yamashita, Yaxiaer Yalikun, Satoshi Amaya, Asako Sato, Viola Vogel, Yo Tanaka
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: - Pages: 256-264

    • DOI

      10.1016/j.snb.2019.04.087

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Earthworm muscle driven valve with both electrical and chemical controls2018

    • Author(s)
      Yo Tanaka, Shun-ichi Funano, Yuji Noguchi, Yaxiaer Yalikun, Norihiro Kamamichi
    • Journal Title

      Proceeding of Micro Total Analysis Systems

      Volume: - Pages: 707-709

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Earthworm muscle-tissue actuated atmospheric-operable 3D printed wheel runner2018

    • Author(s)
      Yaxiaer Yalikun, Yuji Noguchi, Norihiro Kamamichi, Yo Tanaka
    • Journal Title

      Proceeding of Micro Total Analysis Systems

      Volume: - Pages: 1012-1014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Earthworm muscle driven bio-micropump2017

    • Author(s)
      Yo Tanaka, Yuji Noguchi, Yaxiaer Yalikun, Norihiro Kamamichi
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 242 Pages: 1186-1192

    • DOI

      10.1016/j.snb.2016.09.123

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Earthworm muscle driven valve with both electrical and chemical controls2018

    • Author(s)
      Yo Tanaka, Shun-ichi Funano, Yuji Noguchi, Yaxiaer Yalikun, Norihiro Kamamichi
    • Organizer
      The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Earthworm muscle-tissue actuated atmospheric-operable 3D printed wheel runner2018

    • Author(s)
      Yaxiaer Yalikun, Yuji Noguchi, Norihiro Kamamichi, Yo Tanaka
    • Organizer
      The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 集積バイオデバイス研究チーム

    • URL

      http://ibd.riken.jp/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.qbic.riken.jp/ibd/jpn/

    • Related Report
      2017 Research-status Report
  • [Remarks] 理化学研究所 集積バイオデバイス研究ユニット

    • URL

      http://www.qbic.riken.jp/ibd/jpn/

    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Funded Workshop] RIKEN Engineering Network Workshop - Fusion of tolerance function of life and engineering -2018

    • Related Report
      2018 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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