OTN-NIR fluorescence nanothermal imaging by using ceramic nanoparticles

• Project/Area Number: 15K14131
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Inorganic materials/Physical properties
• Research Institution: Tokyo University of Science
• Principal Investigator: SOGA Kohei 東京理科大学, 基礎工学部, 教授 (50272399)
• Co-Investigator(Kenkyū-buntansha): KAMIMURA Masao 東京理科大学, 基礎工学部, 助教 (80706888) ; KISHIMOTO Hidehiro 琉球大学大学, 大学院医学研究科, 教授 (80251213) ; YOKOTA Hideo 独立行政法人理化学研究所, チームリーダー (00261206)
• Project Period (FY): 2015-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: ナノ温度イメージング / OTN近赤外 / バイオイメージング / 蛍光 / 希土類 / セラミックス / ナノ粒子 / 近赤外 / OTN

Outline of Final Research Achievements

OTN-NIR fluorescence bioimging can achieve several cm observation depth, which is ten times deeper than the current imaging with shorter wavelength. By developing the OTN-NIR fluorescence nanothermometry probe, we can achieve nanothermometry without suffered by non-color-fading, non-phototoxic and much deeper fluorescence bioimging. As a result of project, by ligand exchange onto oleic acid modified beta NaYF4 nanoparticle, monodispersed hydrophilic OTN-NIR fluorescence nanothermometry probe was synthesized. Also, temperature-controlled stage was installed onto the OTN-NIR fluorescence bioimaging microscope for the OTN-NIR fluorescence nanothermal imaging.

Research Products

• [Presentation] 近赤外蛍光ナノ粒子を利用するナノ温度イメージング (2016)
  • Author(s): 上村 真生、曽我 公平
  • Organizer: 日本化学会 第96春季年会
  • Place of Presentation: 同志社大学 京田辺キャンパス
  • Year and Date: 2016-03-24
  • Invited
• [Presentation] Probe Design and Processing for Biophotonics in the Second Biological Window (2016)
  • Author(s): Kohei SOGA, Masao KAMIMURA
  • Organizer: ," The 5th International Solvothermal and Hydrothermal Association Conference (ISHA 2016)
  • Place of Presentation: NCKU, Tainan, Taiwan, R. O. C.
  • Year and Date: 2016-01-17
  • Int'l Joint Research / Invited
• [Presentation] SBWイメージングの現状と課題, (2015)
  • Author(s): 曽我公平、竹内司、横田秀夫、岸本英博
  • Organizer: 第24回日本バイオイメージング学会学術集会
  • Place of Presentation: 東京理科大学葛飾キャンパス
  • Year and Date: 2015-09-26
  • Invited
• [Presentation] Surface Modified Rare-earth Doped Ceramic Nanophosphors for Fluorescence Bioimaging and Nanothermometry in the Second Biological Window (2015)
  • Author(s): Masao Kamimura, Kohei Soga
  • Organizer: 2015 International Symposium on Chemical and Polyscale Technologies for Biomedical Application and Environmental Sustainability (ISCPT)
  • Place of Presentation: Chientan Youth Activity Center, Taipei, Taiwan
  • Year and Date: 2015-09-06
  • Int'l Joint Research / Invited