Fabrication of drug-release type implant using amorphous calcium phosphate film as a carrier
| Project/Area Number |
15K14142
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Composite materials/Surface and interface engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
Ueda Kyosuke 東北大学, 工学研究科, 准教授 (40507901)
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| Co-Investigator(Kenkyū-buntansha) |
成島 尚之 東北大学, 工学研究科, 教授 (20198394)
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| Co-Investigator(Renkei-kenkyūsha) |
KANETAKA Hiroyasu 東北大学, 大学院歯学研究科, 准教授 (50292222)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 生体材料 / 材料加工・処理 / 非晶質リン酸カルシウム / コーティング / 薬剤徐放 / 骨形成タンパク質 / リン酸カルシウムコーティング |
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| Outline of Final Research Achievements |
Bone morphogenetic protein (BMP) was loaded on amorphous calcium phosphate (ACP) film by immersion in BMP-2 solution. The releasing behavior of BMP-2 from ACP film was evaluated. The amount of BMP-2 loaded on ACP film by immersion in PBS(-) without heparin was higher than that with heparin. The BMP-2 loaded on ACP film by immersion in PBS(-) without heparin was released continuously for 12 h.
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Report
(3 results)
Research Products
(33 results)
