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Smart Ferrofluid with Quick Gel Transformation in Tumors for MRI-Guided Local Magnetic Thermochemotherapy

Research Project

Project/Area Number 15K14146
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Composite materials/Surface and interface engineering
Research InstitutionKyushu University (2017)
Nagoya University (2015-2016)

Principal Investigator

Hayashi Koichiro  九州大学, 歯学研究院, 准教授 (80580886)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords磁性流体 / スマート材料 / 生体材料 / DDS / 温熱療法 / スマートマテリアル / ハイブリッドマテリアル / ハイブリッド / ハイパーサーミア / MRI / ナノ医療 / セラノスティクス / MRI / DDS
Outline of Final Research Achievements

I successfully developed smart ferrofluid that transforms immediately into a gel in tumors and generates heat in response to an alternating magnetic field (AMF), simultaneously releasing the anticancer drug. The smart ferrofluid, which is synthesized using less toxic magnetic materials, natural polysaccharides, and amino acids, can also act as a contrast agent for MRI. The ferrofluid also incorporates an anticancer drug (i.e., doxorubicin, DOX) via hydrogen bonds. AMF causes heating of gels prepared from the DOX-containing ferrofluid, resulting in gel shrinkage and DOX release. In vivo experiments demonstrated that the ferrofluid transforms into a gel in the tumor, with the gel remaining in the tumor. Furthermore, magnetic thermochemotherapy using this ferrofluid inhibited tumor growth, while magnetic hyperthermia alone had only a marginal effect. Thus, the combination of magnetic hyperthermia and chemotherapy may be important for suppressing tumor growth.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(40 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results,  Acknowledgement Compliant: 7 results,  Open Access: 2 results) Presentation (11 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results) Remarks (4 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] Fabrication and Evaluation of Interconnected Porous Carbonate Apatite from Alpha Tricalcium Phosphate Spheres2019

    • Author(s)
      Kunio Ishikawa, Tya Arifta, Koichiro Hayashi, Kanji Tsuru
    • Journal Title

      JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

      Volume: 印刷中 Pages: 269-277

    • DOI

      10.1002/jbm.b.34117

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organic-Inorganic Hybrid Hollow Nanoparticles Suppress Oxidative Stress and Repair Damaged Tissues for Treatment of Hepatic Fibrosis2018

    • Author(s)
      Koichiro Hayashi, Takuma Maruhashi, Wataru Sakamoto, Toshinobu Yogo
    • Journal Title

      Advanced Functional Materials

      Volume: 28 Pages: 1706332-1706332

    • DOI

      10.1002/adfm.201706332

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Red blood cell-like particles with the ability to avoid lung and spleen accumulation for the treatment of liver fibrosis2018

    • Author(s)
      K. Hayashi, S. Yamada, W. Sakamoto, T. Yogo
    • Journal Title

      Biomaterials

      Volume: 156 Pages: 45-55

    • DOI

      10.1016/j.biomaterials.2017.11.031

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellulose-based molecularly imprinted red-blood-cell-like microparticles for the selective capture of cortisol2018

    • Author(s)
      K. Hayashi, H. Hayashi, S. Yamada, W. Sakamoto, T. Yogo
    • Journal Title

      CARBOHYDRATE POLYMERS

      Volume: 193 Pages: 173-178

    • DOI

      10.1016/j.carbpol.2018.03.095

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective impairment of myeloma cells and their progenitors by hyperthermia.2018

    • Author(s)
      Hirokazu Miki, Shingen Nakamura, Asuka Oda, Hirofumi Tenshin, Jumpei Teramachi, M. Hiasa, A. Bat-Erdene, Y. Maeda, M. Oura, M. Takahashi, M. Iwasa, T. Harada, S. Fujii, K. Kurahashi, S. Yoshida, K. Kagawa, I. Endo, K. Aihara, M. Ikuo, K. Itoh, Koichiro Hayashi, Michihiro Nakamura, Masahiro Abe
    • Journal Title

      Oncotarget.

      Volume: 9 Pages: 10307-10316

    • DOI

      10.18632/oncotarget.23121

    • NAID

      120006576960

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Lead-Free Piezoelectric Li2CO3-Added (Ba,Ca)(Ti,Sn)O3 Ceramics under Controlled Low Oxygen Partial Pressure and Their Properties2018

    • Author(s)
      Kouta Noritake, Wataru Sakamoto, Isamu Yuitoo, Teruaki Takeuchi, Koichiro Hayashi, Toshinobu Yogo
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 2 Pages: 021501-021501

    • DOI

      10.7567/jjap.57.021501

    • NAID

      210000148589

    • ISSN
      0021-4922, 1347-4065
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 磁場を使った医療技術2018

    • Author(s)
      林幸壱朗
    • Journal Title

      現代化学

      Volume: 3 Pages: 15-15

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organic-Inorganic Hybrid Nanoparticles for Tracking the Same Cells Seamlessly at the Cellular, Tissue, and Whole Body Levels2017

    • Author(s)
      Koichiro Hayashi, Yusuke Sato, Hiroki Maruoka, Wataru Sakamoto, Toshinobu Yogo
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 印刷中 Pages: 1129-1135

    • DOI

      10.1021/acsbiomaterials.7b00181

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Relaxometric Property of Organosilica Nanoparticles Internally Functionalized with Iron Oxide and Fluorescent Dye for Multimodal Imaging2017

    • Author(s)
      Michihiro Nakamura, Koichiro Hayashi, Hitoshi Kubo, Takafumi Kanadani, Masafumi Harada, Toshinobu Yogo
    • Journal Title

      Journal of Colloid and Interface Science

      Volume: 492 Pages: 127-135

    • DOI

      10.1016/j.jcis.2017.01.004

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mesoscopic Multimodal Imaging Provides New Insight to Tumor Tissue Evaluation: An Example of Macrophage Imaging of Hepatic Tumor using Organosilica Nanoparticles2017

    • Author(s)
      Michihiro Nakamura, Koichiro Hayashi, Hitoshi Kubo, Masafumi Harada, Keisuke Izumi, Yoshihiro Tsuruo, Toshinobu Yogo
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 3953-3953

    • DOI

      10.1038/s41598-017-04043-7

    • NAID

      120006650111

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metallic Glass Separators for Fuel Cells at Intermediate Temperatures2017

    • Author(s)
      Masaya Takemoto, Masatomo Hattori, Koichiro Hayashi, Shin-ichi Yamaura, Wei Zhang, Wataru Sakamoto, Toshinobu Yogo
    • Journal Title

      Materials Letters

      Volume: 206 Pages: 87-90

    • DOI

      10.1016/j.matlet.2017.06.115

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Inorganic-organic Hybrid Membranes Consisting of Organotrisiloxane Linkages and Their Fuel Cell Properties at Intermediate Temperatures2017

    • Author(s)
      Masaya Takemoto, Koichiro Hayashi, Shin-ichi Yamaura, Wei Zhang, Wataru Sakamoto, Toshinobu Yogo
    • Journal Title

      Polymer

      Volume: 120 Pages: 021501-021501

    • DOI

      10.1016/j.polymer.2017.05.065

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 診断・治療用有機-無機ハイブリッドナノ粒子の開発2017

    • Author(s)
      林幸壱朗
    • Journal Title

      セラミックデータブック2017/2018

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Theranostic Nanoparticles for MRI-Guided Thermochemotherapy: Tight Clustering of Magnetic Nanoparticles Boosts Relaxivity and Heat-Generation Power2017

    • Author(s)
      Koichiro Hayashi, Yoshitaka Sato, Wataru Sakamoto, Toshinobu Yogo
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 3 Pages: 95-105

    • DOI

      10.1021/acsbiomaterials.6b00536

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 光と生体物質に応答する有機-無機ハイブリッド中空ナノ粒子の新規合成法とイメージガイド下三種同時治療2017

    • Author(s)
      林 幸壱朗
    • Journal Title

      セラミックス

      Volume: 52 Pages: 130-133

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] One-Pot Synthesis of Dual Stimulus-Responsive Degradable Hollow Hybrid Nanoparticles for Image-guided Trimodal Therapy2016

    • Author(s)
      Koichiro Hayashi, Takuma Maruhashi, Wataru Sakamoto, Toshinobu Yogo
    • Journal Title

      Advanced Functional Materials

      Volume: 26 Pages: 8613-8622

    • DOI

      10.1002/adfm.201603394

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of Inorganic-Organic Hybrid Membranes Consisting of Triazole Linkages Formed by the Azide-Alkyne Click Reaction2016

    • Author(s)
      Naoya Ozawa, Koichiro Hayashi, Shin-ichi Yamaura, Wei Zhang, Wataru Sakamoto, Toshinobu Yogo
    • Journal Title

      Journal of Membrane Science

      Volume: 517 Pages: 21-29

    • DOI

      10.1016/j.memsci.2016.06.019

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Photocurrent Enhancement of Chemically Synthesized Ag Nanoparticle-Embedded BiFeO3 Thin Films2016

    • Author(s)
      Rika Maruyama, Wataru Sakamoto, Isamu Yuitoo, Teruaki Takeuchi, Koichiro Hayashi, Toshinobu Yogo
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 10S Pages: 10TA14-10TA14

    • DOI

      10.7567/jjap.55.10ta14

    • NAID

      120005905590

    • ISSN
      0021-4922, 1347-4065
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] One-Pot Synthesis of Inorganic/Organic Hybrid Membranes from Organoalkoxysilane, Hydroimidazole Derivative, and Cyclic Sulfonic Acid Ester2016

    • Author(s)
      Koji Takahashi, Junji Umeda, Koichiro Hayashi, Wataru Sakamoto, Toshinobu Yogo
    • Journal Title

      Journal of Materials Science

      Volume: 51 Pages: 3398-3407

    • DOI

      10.1007/s10853-015-9654-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multifunctional silica-based hybrid nanoparticles for biomedical applications2016

    • Author(s)
      Koichiro Hayashi
    • Journal Title

      J. Ceram. Soc. Japan

      Volume: 124 Issue: 9 Pages: 855-862

    • DOI

      10.2109/jcersj2.16099

    • NAID

      130005263110

    • ISSN
      1348-6535, 1882-0743
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Smart Ferrofluid with Quick Gel Transformation in Tumors for MRI-Guided Local Magnetic Thermochemotherapy2016

    • Author(s)
      Koichiro Hayashi, Wataru Sakamoto, Toshinobu Yogo
    • Journal Title

      Advanced Functional Materials

      Volume: 26 Pages: 1708-1718

    • DOI

      10.1002/adfm.201504215

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] One-Pot Synthesis of Dual Stimulus-Responsive Degradable Organic-Inorganic Hybrid Hollow Nanoparticles for Fluorescence Image-Guided Trimodal Therapy2017

    • Author(s)
      Koichiro Hayashi
    • Organizer
      BIT’s 7th Annual World Congress of Nano Science & Technology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] One-Pot Synthesis of Organic-Inorganic Hybrid Hollow Nanoparticles for Fluorescence Image-Guided Trimodal Therapy2017

    • Author(s)
      Koichiro Hayashi
    • Organizer
      2nd International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多機能性ナノ・マイクロ粒子の作製と生物医学応用2017

    • Author(s)
      林 幸壱朗
    • Organizer
      日本ゾル-ゲル学会第15回討論会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Dual Stimulus-Responsive Degradable Hollow Organic-Inorganic Hybrid Nanoparticles for Image-Guided Trimodal Therapy2016

    • Author(s)
      Koichiro Hayashi, Takuma Maruhashi, Wataru Sakamoto, and Toshinobu Yogo
    • Organizer
      The 1st International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development
    • Place of Presentation
      大阪
    • Year and Date
      2016-10-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 赤血球様粒子の作製と体内動態の解明2016

    • Author(s)
      林 幸壱朗、山田 翔太、坂本 渉、余語 利信
    • Organizer
      第 32 回日本 DDS 学会学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2016-06-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 多機能ハイブリッドナノ粒子の合成とイメージングおよび 治療への応用2016

    • Author(s)
      林 幸壱朗, 佐藤 裕介, 丸橋 卓磨, 坂本 渉, 余語 利信
    • Organizer
      日本セラミックス協会 2016年年会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2016-03-14
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Multifunctional Nanoparticles for MRI-Guided Magnetic Thermochemotherapy2016

    • Author(s)
      Koichiro Hayashi, Yoshitaka Sato, Wataru Sakamoto, Toshinobu Yogo
    • Organizer
      BIT’s 2nd Annual World Congress of Smart Materials-2016
    • Place of Presentation
      Singapore
    • Year and Date
      2016-03-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ハイブリッドナノ粒子のバイオメディカル応用2016

    • Author(s)
      林 幸壱朗
    • Organizer
      平成28年度日本セラミックス協会東海支部学術研究発表会
    • Place of Presentation
      名古屋
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Core-Shell Nanoparticles for the Combination of Magnetic Hyperthermia and Chemotherapy2015

    • Author(s)
      Koichiro Hayashi, Yoshitaka Sato, Wataru Sakamoto, Toshinobu Yogo
    • Organizer
      ISETS’15 International Symposium on EcoTopia Science 2015 - Innovation for Smart Sustainable Society -
    • Place of Presentation
      Nagoya University
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 交流磁場応答性スマート コア-シェルナノ粒子の合成と 磁気温熱化学療法への応用2015

    • Author(s)
      林幸壱朗, 佐藤嘉崇, 坂本渉, 余語利信
    • Organizer
      日本セラミックス協会第28回秋季シンポジウム
    • Place of Presentation
      富山大学
    • Year and Date
      2015-09-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Clustered Magnetic Nanoparticles-Polymer Core-Shell Nanoparticles for Magnetic Thermochemotherapy2015

    • Author(s)
      Koichiro Hayashi
    • Organizer
      EMN Phuket Meeting 2015: Energy, Materials, and Nanotechnology
    • Place of Presentation
      Phuket
    • Year and Date
      2015-05-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks]

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K006777/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      https://hayashi81.wixsite.com/imasslab2

    • Related Report
      2016 Research-status Report
  • [Remarks]

    • URL

      http://profs.provost.nagoya-u.ac.jp/view/html/100007892_ja.html

    • Related Report
      2016 Research-status Report
  • [Remarks]

    • URL

      http://researchmap.jp/hayashi_/

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] フローサイトメトリー用蛍光プローブ及び蛍光標識細胞の選別方法2017

    • Inventor(s)
      林幸壱朗, 坂本渉, 余語利信, 丸岡弘規
    • Industrial Property Rights Holder
      林幸壱朗, 坂本渉, 余語利信, 丸岡弘規
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-02-10
    • Related Report
      2016 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 蛍光プローブ、蛍光検出方法及び蛍光プローブの使用方法2017

    • Inventor(s)
      林幸壱朗, 坂本渉, 余語利信, 丸岡弘規
    • Industrial Property Rights Holder
      林幸壱朗, 坂本渉, 余語利信, 丸岡弘規
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-02-10
    • Related Report
      2016 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] フローサイトメトリー用蛍光プローブ及び蛍光標識細胞の選別方法2016

    • Inventor(s)
      林幸壱朗, 坂本渉, 余語利信, 丸岡弘規
    • Industrial Property Rights Holder
      林幸壱朗, 坂本渉, 余語利信, 丸岡弘規
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-091356
    • Filing Date
      2016-04-28
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 蛍光プローブ、蛍光検出方法及び蛍光プローブの使用方法2016

    • Inventor(s)
      林幸壱朗, 坂本渉, 余語利信, 丸岡弘規
    • Industrial Property Rights Holder
      林幸壱朗, 坂本渉, 余語利信, 丸岡弘規
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-091359
    • Filing Date
      2016-04-28
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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