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Development of bone function-mimetic metallic implants that is recognized as "bone" itself

Research Project

Project/Area Number 15K14167
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Structural/Functional materials
Research InstitutionOsaka University

Principal Investigator

Nakano Takayoshi  大阪大学, 工学研究科, 教授 (30243182)

Co-Investigator(Kenkyū-buntansha) 石本 卓也  大阪大学, 工学研究科, 准教授 (50508835)
當代 光陽  大阪大学, 工学研究科, 助教 (10610800)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords金属粉末積層造形法 / 形状制御 / 組織制御 / 異方性 / 集合組織 / 多孔体 / 金属積層造形法 / インプラント / 力学機能制御 / 低ヤング率化 / 積層造形法 / 骨力学機能 / 低ヤング率
Outline of Final Research Achievements

We challenged the development of metal implant materials for bone replacement that is recognized as bone itself by controlling the anisotropies of shape and microstructure under a metal additive manufacturing technology. For the shape control, arbitrary configuration of solid part enabled control of wide range of Young's modulus with isotropic and uni-, bi-, and tri-axial anisotropies. For the microstructural control, crystallographic texture was controlled by scan strategy of heat source. <001> preferential orientation was realized, which resulted in low Young's modulus in the <001> oriented direction. We achieved a highly functionalized implant materials under additive manufacturing controlling the shape and microstructural anisotropies.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] 3Dプリンタの医療デバイスへの応用2016

    • Author(s)
      中野貴由, 石本卓也
    • Journal Title

      月刊機能材料

      Volume: 36 Pages: 40-46

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3Dプリンタを活用した機能性構造材料の創製 -骨・骨関節代替用材料-2016

    • Author(s)
      中野貴由
    • Journal Title

      工業材料

      Volume: - Pages: 57-62

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Powder/Solid Composites Possessing Low Young’s Modulus and Tunable Energy Absorption Capacity, Fabricated by Electron Beam Melting, for Biomedical Applications2015

    • Author(s)
      N. Ikeo, T. Ishimoto and T. Nakano
    • Journal Title

      Journal of Alloys and Compounds

      Volume: 639 Pages: 336-340

    • DOI

      10.1016/j.jallcom.2015.03.141

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Solid/Powder Clad Ti-6Al-4V Alloy with Low Young&rsquo;s Modulus and High Toughness Fabricated by Electron Beam Melting2015

    • Author(s)
      N. Ikeo, T. Ishimoto, N. Hiramoto, H. Fukuda, H. Ogisu, Y. Araki and T. Nakano
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 56 Issue: 5 Pages: 755-758

    • DOI

      10.2320/matertrans.M2015025

    • NAID

      130005065985

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Comparison of microstructure and mechanical property of Ti-15Mo-5Zr-3Al alloy fabricated by electron and laser beam melting2017

    • Author(s)
      S.-H. Sun, K. Hagihara, T. Ishimoto, T. Nakano
    • Organizer
      日本金属学会2017年春期(第160回)大会
    • Place of Presentation
      首都大学東京
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 金属粉末積層造形法による生体用βTi型チタン合金製部材の作製と集合組織形成2016

    • Author(s)
      石本卓也, 久本健太, 中野貴由
    • Organizer
      粉体粉末冶金協会平成28年度秋季大会
    • Place of Presentation
      東北大学(青葉山キャンパス)
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] レーザ積層造形法による混合粉末からの Ti 合金造形体作製2016

    • Author(s)
      堀敬雄, 當代光陽, 孫世海, 中野貴由
    • Organizer
      日本金属学会2016年秋期(第159回)大会
    • Place of Presentation
      大阪大学豊中キャンパス
    • Year and Date
      2016-09-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 付加製造法によるβ型チタン合金緻密体の造形と組織制御2016

    • Author(s)
      久本健太, 石本卓也, 蘇亜拉図, 中野貴由
    • Organizer
      粉体粉末冶金協会平成28年度春季大会
    • Place of Presentation
      京都工芸繊維大学
    • Year and Date
      2016-05-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of a new powder/solid composite for Ti alloy implants exhibiting mechanical properties similar to bone anisotropy by metal additive biomanufacturing2016

    • Author(s)
      T. Nakano, H. Hidetsugu, T. Inoue, T. Ishimoto, A. Matsugaki
    • Organizer
      10th World Biomaterials Congress (WBC)
    • Place of Presentation
      Palais des congres de Montreal, Montreal, Quebec, Canada
    • Year and Date
      2016-05-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 積層造形法による生体用β型Ti合金部材の作製と組織形成2016

    • Author(s)
      久本健太, 石本卓也, 蘇亜拉図, 中野貴由
    • Organizer
      日本金属学会2016年春期(第158回)大会
    • Place of Presentation
      東京理科大学葛飾キャンパス, 東京
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 金属積層造形法を用いた構造体化制御による異方性骨インプラント材料の創製2015

    • Author(s)
      井上暢, 石本卓也, 蘇亜拉図, 孫世海, 中野貴由
    • Organizer
      日本金属学会2015年秋期(第157回)大会
    • Place of Presentation
      九州大学, 福岡
    • Year and Date
      2015-09-16
    • Related Report
      2015 Research-status Report
  • [Presentation] New powder/solid composite of Ti alloys exhibiting low Young’s modulus for biomedical applications fabricated by additive manufacturing2015

    • Author(s)
      T. Nakano, T. Inoue, T. Ishimoto, N. Ikeo
    • Organizer
      日本金属学会2015年秋期(第157回)大会
    • Place of Presentation
      九州大学, 福岡
    • Year and Date
      2015-09-16
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] New powder/solid composite exhibiting low Young’s modulus and energy absorption for biomedical applications fabricated by additive manufacturing2015

    • Author(s)
      T. Nakano, N. Ikeo, T. Ishimoto, T. Inoue
    • Organizer
      Ti-2015: The 13th World Conference on Titanium
    • Place of Presentation
      Manchester Grand Hyatt, San Diego, California, USA
    • Year and Date
      2015-08-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 積層造形法を用いた構造制御によるチタン合金の異方的力学機能設計2015

    • Author(s)
      井上暢, 平本菜摘, 石本卓也, 芹澤愛, 福田英次, 中本貴之, 木村貴広, 中野貴由
    • Organizer
      軽金属学会第128回春期大会
    • Place of Presentation
      東北大学, 仙台
    • Year and Date
      2015-05-16
    • Related Report
      2015 Research-status Report
  • [Remarks] 大阪大学大学院工学研究科中野研究室HP

    • URL

      http://www.mat.eng.osaka-u.ac.jp/msp6/nakano/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 大阪大学大学院工学研究科 中野研究室HP

    • URL

      http://www.mat.eng.osaka-u.ac.jp/msp6/nakano/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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