| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Inspired by the reaction mechanism of mononuclear nonheme iron enzyme, SyrB2, which catalyzes direct halogenation of alkane C-H bonds under mild conditions, novel fluorination catalysts have been designed. SyrB2 generates nonheme oxoiron(IV) species as an active oxidant, which has a halogen ligand coordinated cis to the oxygen ligand. In order to reproduce the biological oxidant, new iron complexes that contain two cis-labile coordination sites have been synthesized. Some fluorinated products have been obtained using the catalysts under mild conditions.
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