Neural circuits that distinguish memory processes in the fly brain

• Project/Area Number: 15K14307
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Tohoku University
• Principal Investigator: Tanimoto Hiromu 東北大学, 生命科学研究科, 教授 (70714955)
• Research Collaborator: YAMAGATA Nobuhiro 東北大学, 大学院生命科学研究科, 助教 (50716248) ; ICHINOSE Toshiharu 東北大学, 生命科学研究科, 研究支援者 (20774748)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経情報処理

Outline of Final Research Achievements

Fruit flies Drosophila melanogaster bidirectionally adapt the response to an odor based on appetitive and aversive memories of sugar reward and electric shock punishment, respectively. Accumulating evidence suggest that the output from a brain structure called the mushroom body (MB) is necessary for acquisition, consolidation, and retrieval of appetitive and aversive memories. However, it is largely unclear how the common MB circuit operates these distinct memory processes. To comprehensively characterize the organization of the MB output, we anatomically identified all the MB output neuron types in Drosophila. By measuring the behavioral importance of each output pathway, we found that the different sets of the MB output neurons are recruited in appetitive and aversive memories. Furthermore, our comprehensive behavioral analysis revealed acquisition, consolidation and retrieval of memories are characterized by the combinatorial functions of MB output neurons.

Research Products

• [Int'l Joint Research] Max Planck Institute of Neurobiology/University of Munich(Germany)
• [Int'l Joint Research] HHMI Janelia Research Campus/Cold Spring Harbor Laboratory(米国)
• [Int'l Joint Research] Max Planck Institute of Neurobiology(Germany)
• [Int'l Joint Research] HHMI Janelia Research Campus(米国)
• [Journal Article] Suppression of dopamine neurons mediates reward. (2016)
  • Author(s): Yamagata N, Hiroi M, Kondo S, Abe A, Tanimoto, H.
  • Journal Title: PLoS Biol Volume: 14(12) Issue: 12 Pages: e1002586-e1002586
  • DOI: 10.1371/journal.pbio.1002586
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dynamics of memory-guided choice behavior in <i>Drosophila</i> (2016)
  • Author(s): Rohwedder A, Wenz NL, Stehle B, Huser A, Yamagata N, Zlatic M, Truman JW, Tanimoto H, Saumweber T, Gerber B.
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 92 Issue: 8 Pages: 346-357
  • DOI: 10.2183/pjab.92.346
  • NAID: 130005420972
  • ISSN: 0386-2208, 1349-2896
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Direct neural pathways convey distinct visual information to Drosophila mushroom bodies. (2016)
  • Author(s): Vogt K, Aso Y, Hige T, Knapek S, Ichinose T, Friedrich AB, Turner GC, Rubin GM, Tanimoto H.
  • Journal Title: eLife Volume: in press
  • DOI: 10.7554/elife.14009
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reward signal in a recurrent circuit drives appetitive long-term memory formation. (2015)
  • Author(s): Ichinose T, Aso Y, Yamagata N, Abe A, Rubin GM, Tanimoto H.
  • Journal Title: eLife Volume: 4 Pages: 1-18
  • DOI: 10.7554/elife.10719
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Visualization and neuronal control of memory-guided choice behaviour. (2017)
  • Author(s): Tanimoto H.
  • Organizer: Janelia Farm Conference “Structure and Function of the Insect Mushroom Body”
  • Place of Presentation: Verginia, USA
  • Year and Date: 2017-03-05
  • Int'l Joint Research / Invited
• [Presentation] Neural pathways for the formation, consolidation, and retrieval of memory in the fly brain. (2016)
  • Author(s): Tanimoto H.
  • Organizer: The 6th International Symposium on "Biology of Decision Making"
  • Place of Presentation: Paris, France
  • Year and Date: 2016-05-25
  • Int'l Joint Research / Invited
• [Presentation] 嗅覚連合記憶の異なる素過程におけるキノコ体出力パターンの解析 (2015)
  • Author(s): 菅野 舞, 市之瀬 敏晴, 谷本 拓.
  • Organizer: 第38回日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] Dopamine circuits and memory formation. (2015)
  • Author(s): Tanimoto H.
  • Organizer: 14th European Symposium for Insect Taste and Olfaction
  • Place of Presentation: Residence Hotel Cormoran, Cagliari (Italy)
  • Year and Date: 2015-09-20
  • Int'l Joint Research / Invited
• [Presentation] Mushroom body reward circuits. (2015)
  • Author(s): Tanimoto H.
  • Organizer: The EMBO-Kavli Workshop on Neural Circuits and Behaviour of Drosophila
  • Place of Presentation: Orthodox academy of Crete, Hania (Greece)
  • Year and Date: 2015-07-05
  • Int'l Joint Research / Invited
• [Presentation] Dopamine circuits for memory formation. (2015)
  • Author(s): Tanimoto H.
  • Organizer: 3rd Asia-Pacific Drosophila Research Conference
  • Place of Presentation: Beijing Conference Center, Beijing (China)
  • Year and Date: 2015-05-11
  • Int'l Joint Research / Invited