Elucidation of the mechanism of modulation of synaptic transmission by the regulation of intracellular calcium release
Project/Area Number |
15K14309
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 神経科学 / 生理学 / 生体分子 / 脳・神経 / 遺伝子 / シナプス伝達 / 可塑性 / カルシウム |
Outline of Final Research Achievements |
In this study, we tried to elucidate roles of molecules that regulate calcium dynamics. We analyzed the functions of the molecules whose roles in calcium dynamics are not well known, using synapse site-specific gene-targeted mice. In the electrophysiological analysis with hippocampal slices, long-term potentiation of excitatory synaptic transmission was significantly reduced in postsynaptic site-specific Molecule A-deficient mice, whereas synaptic responses were increased during prolonged low-frequency stimulation in presynaptic terminal-specific Molecule A-deficient mice. We also found the possibility of the impairment in behavioral tests in Molecule B-deficient mice.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.2016
Author(s)
Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M.
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Journal Title
Nat Communications
Volume: 7
Issue: 1
Pages: 10594-10594
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus.2016
Author(s)
Kobayashi S, Hida Y, Ishizaki H, Inoue E, Tanaka-Okamoto M, Yamasaki M, Miyazaki T, Masahiro F, Kitajima I, Takai Y, Watanabe M, Ohtsuka T, Manabe T
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Journal Title
Eur J Neurosci.
Volume: 44
Issue: 5
Pages: 2272-2284
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Generation and characterization of calsyntenin triple knockout mice2017
Author(s)
Mori, K., Koebis, M., Ohno, H., Kobayashi, S., Manabe, T., Aiba, A. and Iino, Y.
Organizer
The Physiological Society of Japan, The 94th Annual Meeting
Place of Presentation
アクトシティー浜松(静岡県浜松市)
Year and Date
2017-03-30
Related Report
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