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Construction of miminal circuits that can support behaviors

Research Project

Project/Area Number 15K14310
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionThe University of Tokyo

Principal Investigator

IINO YUICHI  東京大学, 大学院理学系研究科(理学部), 教授 (40192471)

Co-Investigator(Renkei-kenkyūsha) OHNO Hayao  東京大学, 大学院理学系研究科, 特任助教 (00747272)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords最小回路 / 合成生物学 / 化学走性 / シンタキシン / 行動 / 走化性
Outline of Final Research Achievements

To avoid intrinsic problem of functional redundancy and parallel processing pathways in analyzing neural circuits, we generated neural circuits from starting null circuit by using synaptic transmission mutant. We successfully regenerated growth, locomotion and mechanical responses.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Calcium dynamics regulating the timing of decision-making in C. elegans2017

    • Author(s)
      Tanimoto Yuki、Yamazoe-Umemoto Akiko、Fujita Kosuke、Kawazoe Yuya、Miyanishi Yosuke、Yamazaki Shuhei J、Fei Xianfeng、Busch Karl Emanuel、Gengyo-Ando Keiko、Nakai Junichi、Iino Yuichi、Iwasaki Yuishi、Hashimoto Koichi、Kimura Koutarou D
    • Journal Title

      eLife

      Volume: 6

    • DOI

      10.7554/elife.21629

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dynamics of Presynaptic Diacylglycerol in a Sensory Neuron Encode Differences Between Past and Current Stimulus Intensity2017

    • Author(s)
      Ohno H, Sakai N, Adachi T, Iino Y.
    • Journal Title

      Cell Reports

      Volume: 20 Issue: 10 Pages: 2294-2303

    • DOI

      10.1016/j.celrep.2017.08.038

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Gustatory Neural Circuit of Caenorhabditis elegans Generates Memory-Dependent Behaviors in Na(+) Chemotaxis.2017

    • Author(s)
      Lifang Wang, Hirofumi Sato, Yohsuke Satoh, Masahiro Tomioka, Hirofumi Kunitomo and Yuichi Iino
    • Journal Title

      J Neurosci

      Volume: 37 Issue: 8 Pages: 2097-2111

    • DOI

      10.1523/jneurosci.1774-16.2017

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Molecular and neural circuit mechanisms for experience-dependent behavioral switching in C. elegans2017

    • Author(s)
      YUICHI IINO
    • Organizer
      37th Blankenese Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Labeling of active neural circuits by the calcium probe CaMPARI2017

    • Author(s)
      Keita Mori, Yu Toyoshima, Yuichi Iino
    • Organizer
      The 21st International C. elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A gustatory neural circuit for experience-dependent behavioral plasticity.2017

    • Author(s)
      Hirofumi Sato, Hirofumi Kunitomo, Xianfeng Fei, Koichi Hashimoto, Yuichi Iino
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of primary interneurons that regulate memory-dependent salt concentration chemotaxis in C. elegans.2017

    • Author(s)
      Hirofumi Kunitomo, Hirofumi Sato and Yuichi Iino.
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A neural circuit for memory-dependent Na+ chemotaxis dissected in Caenorhabditis elegans2016

    • Author(s)
      Lifang WANG, Hirofumi Sato, Yohsuke Sato, Masahiro Tomioka, Hirofumi Kunitomo, Yuichi Iino
    • Organizer
      17th International Symposium on Olfaction and Taste (ISOT2016)
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A neural circuit for experience-dependent salt chemotaxis in C. elegans2016

    • Author(s)
      Hirofumi Sato, Hirofumi Kunitomo, Xianfeng Fei, Koichi Hashimoto, Yuichi Iino
    • Organizer
      CeNeuro2016 (C. elegans Topic Meeting: NEURONAL DEVELOPMENT, SYNAPTIC FUNCTION & BEHAVIOR)
    • Place of Presentation
      名古屋大学豊田講堂(愛知県・名古屋市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neural circuits underlying glucose chemotaxis learning in Caenorhabditis elegans2016

    • Author(s)
      Risshun Chin, Yutaro Ueoka, Chihiro Uchiyama, Keita Katae, Masahiro Tomioka, Yuichi Iino
    • Organizer
      第15回国際シンポジウム「味覚嗅覚の分子神経機構」
    • Place of Presentation
      九州大学(福岡県・福岡市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] いい思いをたどって濃い味に― 線虫の味覚記憶の発見とその神経回路の解明 ―

    • URL

      http://www.s.u-tokyo.ac.jp/ja/press/2017/5236/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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