| Project/Area Number |
15K14313
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | パッチクランプ / 大脳皮質 / マウス / 神経科学 / ドーパミン / 電気生理学 / 神経 |
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| Outline of Final Research Achievements |
To understand the neuronal mechanisms underlying animal behavior, it is essential to perform electrophysiological measurements of membrane potential dynamics of neurons in awake behaving animals with a high temporal resolution in a cell-type specific manner. In this study I verified technical feasibility of cell-type (or projection-target) specific patch-clamp recordings combined with optogenetics using task-performing mice. I successfully recorded membrane potentials of specific cell-types in multiple layers of primary somatosensory cortex of mice exhibiting spontaneous behavior or performing a simple learning task and addressed important questions on neuronal processing of whisker-related tactile information.
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